PAI-1
- CAS No.
- Chemical Name:
- PAI-1
- Synonyms
- PAI-1;ARMAPE;PAI-1, RAT;MOUSE PAI-1;PAI-1, MOUSE;PAI-1, HUMAN;PAI-1, MUTANT, MOUSE;PLASMINOGEN ACTIVATOR INHIBITOR 1;PLASMINOGEN ACTIVATOR INHIBITOR-1, RAT;MOUSE PLASMINOGEN ACTIVATOR INHIBITOR-1
- CBNumber:
- CB1438644
- Molecular Formula:
- C27H47N9O9S
- Molecular Weight:
- 673.78
- MOL File:
- Mol file
PAI-1 Chemical Properties,Uses,Production
Enzyme inhibitor
This 402-residue serine protease inhibitor, or serpin (MW = 45074 g/mol; Abbreviation: PAI-1) binds to and inhibits plasminogen activators-tissuetype plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). This inhibition reduces plasmin production and suppresses dissolution of fibrin clots. Elevated PAI-1 levels correlate with an increased cardiovascular disease risk, a behavior that has also been linked to obesity and metabolic syndrome. Pharmacological suppression of PAI-1 is a likely way to prevent or treat vascular disease. Reduced PAI-1 levels may result in increased fibrinolysis and an associated bleeding diathesis. PAI-1 was initially identified in the 1980s, and the first reported case of PAI-1 deficiency appeared in 1989. Unambiguous proof that PAI-1 deficiency as a cause of a bleeding disorder has been rare, but use of selective PAI inhibitors (See PAI-749) may clarify this point. Because of lack of standardized commercially available PAI-1 activity assay sensitive in the lowest range, the true prevalence of this rare condition has yet to be established.
PAI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
PAI-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| EMD Biosciences, Inc. | 858 450 5500 | United States | 6529 | 66 | Inquiry |
| VWR International | 800 932 5000 | United Kingdom | 6554 | 82 | Inquiry |
| GenScript Corporation | 732 885 9188 | United States | 400 | 77 | Inquiry |
| Wako Pure Chemical Industries, Ltd. | +81 6 6203 3741 | Japan | 6828 | 80 | Inquiry |
| Cortex Biochem, Inc. | 510 568 2228 | United States | 1557 | 77 | Inquiry |
| American Diagnostica Inc. | 1 888 ADI-4HELP | United States | 225 | 59 | Inquiry |
| kemikalieimport | + 45 - 2034 3359 | Europe | 6699 | 47 | Inquiry |
| ecochem international chemical broker | +45 45 42 34 36 | Europe | 6385 | 66 | Inquiry |
| Accurate Chemical & Scientific Corporation. | 516-333-2221 | United States | 6747 | 72 | Inquiry |
| Apollo Scientific Ltd. | 44 161 406 0505 | United Kingdom | 6097 | 88 | Inquiry |