3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE
![3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE Structure](CAS/GIF/14008-79-8.gif)
- CAS No.
- 14008-79-8
- Chemical Name:
- 3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE
- Synonyms
- FC-1;SL6057;Wy 2149;3 CPMT,3CPMT;Chlortropbenzyl hydrochloride;4μ-Chloro-3α-(diphenylmethoxy)tropane hydrochloride;3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE;3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride
- CBNumber:
- CB1445929
- Molecular Formula:
- C21H25Cl2NO
- Molecular Weight:
- 378.34
- MOL File:
- 14008-79-8.mol
- Modify Date:
- 2023/9/20 16:43:00
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE Chemical Properties,Uses,Production
Originator
Clobenztropine,Onbio Inc.
Manufacturing Process
A solution of 28.2 g (0.2 mol) of 3-tropanol is prepared in 50 ml of xylol, and
to this solution is added 23.8 g (0.1 mol) of 4-chlorobenzhydryl chloride. The
resultant solution is heated for 7 h at 145°-155°C, following which the
mixture is cooled and filtered. The clear filtrate thus obtained is washed with
50 ml of 5% aqueous potassium carbonate solution and then with three
successive 25 ml portion of water. The xylol solution is then extracted with
three successive 50 ml portions of 2 N hydrochloric acid. The xylol layer is
discarded and the acid extracts are combined and rendered strongly basic by
the addition of 22.5% aqueous potassium hydroxide, resulting in the
formation of an oily base which separates and which is then extracted with
benzol, from which the benzol is evaporated to yield crude 3-(4'-
chlorobenzhydryloxy)tropane as a brown oil.
2.0 g of 3-(4'-chlorobenzhydryloxy)tropane is treated with 10 ml of 4.5 N
isopropanoic acid hydrogen chloride solution, and the pasty mixture which
results is diluted with approximately 30 ml of absolute ether. A solid product is
formed which is separated by filtration and then washed with absolute ether.
The product is then purified by dissolving it in hot isopropanol, followed by
clarification with activated charcoal. Upon cooling the filtrate, the 3-(4'-
chlorophenylbenzyloxy)tropane separates as a crystalline powder, melting
point 215°-217°C.
In practice it is usually used as hydrochloride.
Therapeutic Function
Antihistaminic
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE Preparation Products And Raw materials
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
BOC Sciences | USA | 0 | 65 | Inquiry | |
Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | China | 4395 | 58 | Inquiry |
RD International Technology Co., Limited | 18024082417 | China | 9268 | 58 | Inquiry |
SIGMA-RBI | 800 736 3690 (Orders) | Switzerland | 6913 | 91 | Inquiry |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | China | 15848 | 69 | Inquiry |
Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
Tocris Bioscience | +44 (0) 117 916 3333 | United Kingdom | 5729 | 77 | Inquiry |
ApexBio Technology | + 1-832-696-8203 | United States | 6254 | 58 | Inquiry |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8141 | 58 | Inquiry |