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Voriconazole (2R,3R)-Isomer

Voriconazole (2R,3R)-Isomer Structure
CAS No.
137234-76-5
Chemical Name:
Voriconazole (2R,3R)-Isomer
Synonyms
Voriconazole 3-Epimer;Voriconazole (2R,3R)-Isomer;Azilsartan medoxomil impurity317;rel-(αR,βR)-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;(αR,βR)-rel-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;4-Pyrimidineethanol, 6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-rel-;(2R,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol compound with (2S,3S);(αR,?βR)?-?rel-6-?Chloro-?α-?(2,?4-?difluorophenyl)?-?5-?fluoro-?β-?methyl-?α-?(1H-?1,?2,?4-?triazol-?1-?ylmethyl)?-4-?pyrimidineethanol;(aR,?bR)?-?rel-6-?Chloro-?α-?(2,?4-?difluorophenyl)?-?5-?fluoro-?β-?methyl-?α-?(1H-?1,?2,?4-?triazol-?1-?ylmethyl)?-4-?pyrimidineethanol;Chloro voriconazole diastereomerQ: What is Chloro voriconazole diastereomer Q: What is the CAS Number of Chloro voriconazole diastereomer
CBNumber:
CB14796241
Molecular Formula:
C16H13ClF3N5O
Molecular Weight:
383.76
MOL File:
137234-76-5.mol
Modify Date:
2023/4/23 13:52:06

Voriconazole (2R,3R)-Isomer Properties

Boiling point 529.9±60.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Dichloromethane (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol
form Solid
pka 11.44±0.29(Predicted)
color White to Off-White

Voriconazole (2R,3R)-Isomer Chemical Properties,Uses,Production

Uses

(αR,?βR)?-?rel-6-?Chloro-?α-?(2,?4-?difluorophenyl)?-?5-?fluoro-?β-?methyl-?α-?(1H-?1,?2,?4-?triazol-?1-?ylmethyl)?-4-?pyrimidineethanol is an intermediate in synthesizing rel-(R,R)-Voriconazole (V759990), The (R,R)-enantiomer of Voriconazole. An antifungal (systemic). An ergosterol biosynthesis inhibitor.

Voriconazole (2R,3R)-Isomer Preparation Products And Raw materials

Raw materials

Preparation Products

Voriconazole (2R,3R)-Isomer (2R,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol compound with (2S,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1- (1H-1,2,4-triazol-1-yl)butan-2-ol (1:1) (αR,βR)-rel-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol 4-Pyrimidineethanol, 6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-rel- Voriconazole 3-Epimer (αR,?βR)?-?rel-6-?Chloro-?α-?(2,?4-?difluorophenyl)?-?5-?fluoro-?β-?methyl-?α-?(1H-?1,?2,?4-?triazol-?1-?ylmethyl)?-4-?pyrimidineethanol (2R,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol compound with (2S,3S) Azilsartan medoxomil impurity317 Chloro voriconazole diastereomerQ: What is Chloro voriconazole diastereomer Q: What is the CAS Number of Chloro voriconazole diastereomer (aR,?bR)?-?rel-6-?Chloro-?α-?(2,?4-?difluorophenyl)?-?5-?fluoro-?β-?methyl-?α-?(1H-?1,?2,?4-?triazol-?1-?ylmethyl)?-4-?pyrimidineethanol rel-(αR,βR)-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol 137234-76-5