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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyrimidines >Chloropyrimidine >Ethyl 2-chloropyrimidine-5-carboxylate

Ethyl 2-chloropyrimidine-5-carboxylate

Ethyl 2-chloropyrimidine-5-carboxylate Structure
CAS No.
89793-12-4
Chemical Name:
Ethyl 2-chloropyrimidine-5-carboxylate
Synonyms
EOS-60350;ETHYL2-CHLOROPYRIMI;2-chloro-pyriMidine-5-carboxylate;Ethyl 2-Chlorpyrimidine-5-carboxylate;2-Chloro-5-(ethoxycarbonyl)pyrimidine;ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;Ethyl 2-chloropyrimidine-5-carboxylate ,97%;2-chloro-pyrimidine-5-carboxylic acid ethyl ester;PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester;5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester
CBNumber:
CB1547225
Molecular Formula:
C7H7ClN2O2
Molecular Weight:
186.6
MOL File:
89793-12-4.mol
Modify Date:
2024/7/2 9:57:38
Request For Quotation

Ethyl 2-chloropyrimidine-5-carboxylate Properties

Melting point 52-60℃
Boiling point 80℃/760mm
Density 1.311±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility soluble in Methanol
pka -3.05±0.22(Predicted)
form Solid
color White to Light yellow
InChI InChI=1S/C7H7ClN2O2/c1-2-12-6(11)5-3-9-7(8)10-4-5/h3-4H,2H2,1H3
InChIKey IEMKQRSOAOPKRJ-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C(C(OCC)=O)C=N1
CAS DataBase Reference 89793-12-4

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Risk Statements  20/21/22
Safety Statements  36/37
HazardClass  IRRITANT
HS Code  29339900
NFPA 704
1
2 0

Ethyl 2-chloropyrimidine-5-carboxylate price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) E1250 Ethyl 2-Chloropyrimidine-5-carboxylate min. 98.0 % 89793-12-4 1G ₹5500 2022-05-26 Buy
Product number Packaging Price Buy
E1250 1G ₹5500 Buy

Ethyl 2-chloropyrimidine-5-carboxylate Chemical Properties,Uses,Production

Chemical Properties

White to light yellow liquid

Uses

Ethyl 2-chloropyrimidine-5-carboxylate is used in the synthesis of Retinoid x receptor agonists (RXR) that are used in the treatment of cancers.

Synthesis

A mixture of 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester (3.60 g, 21 mmol), phosphorus oxychloride (25 mL), and N, N-dimethylaniline (2.5 mL) was heated to reflux for 1.5 h. After removal of the solvent, ice water (10 mL) was added to the residue. The mixture was added to 2 N NaOH (90 ml) and extracted with EtOAc. After work, the residue was purified by column chromatography on silica gel (ethyl acetate in petroleum ether, 5 per cent v/v) to give the product Ethyl 2-chloropyrimidine-5-carboxylate (1.20 g, 30 per cent).

Ethyl 2-chloropyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl potassium malonate Ethanol Ethyl 3-ethoxypropionate N,N-Dimethylformamide Ethyl formate
Toluene Sodium Phosphorus oxychloride Urea N,N-Dimethylaniline
Hydrochloric acid Government regulation Acetic acid Dimethyl sulfate
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Preparation Products

5-Pyrimidinecarbonitrile, 2-chloro- (7CI,8CI) (2-Pyrrolidin-1-ylpyrimidin-5-yl)methanol

Ethyl 2-chloropyrimidine-5-carboxylate Suppliers

Global( 249)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GOALSY PHARMA +91-8247562464 +91-9885583385 Hyderabad, India 479 58 Inquiry
ANAXLABORATORIES PRIVATE LIMITED +91-9177075735 Telangana, India 686 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Reax Chemicals 08048372701Ext 416 Hyderabad, India 4223 58 Inquiry
Nanjing Fred Technology Co., Ltd +86-25-84696168 +86-15380713688 China 2427 58 Inquiry
Lianhe Aigen Pharmatech Co.,Ltd. +undefined+undefined18918657159 China 309 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 16209 58 Inquiry
Supplier Advantage
GOALSY PHARMA 58
ANAXLABORATORIES PRIVATE LIMITED 58
CHEMSWORTH 30
A.J Chemicals 58
TCI Chemicals (India) Pvt. Ltd. 58
Reax Chemicals 58
Nanjing Fred Technology Co., Ltd 58
Lianhe Aigen Pharmatech Co.,Ltd. 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58

Ethyl 2-chloropyrimidine-5-carboxylate Spectrum

ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE(89793-12-4)1HNMRETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE(89793-12-4)FT-IR

89793-12-4(Ethyl 2-chloropyrimidine-5-carboxylate)Related Search:

4,6-Dihydroxypyrimidine 2,5-PYRIDINEDICARBOXYLIC ACID 2-Chloropyrimidine 2-Chloropyrimidine-5-carboxylic acid ethyl 2-chloro-4-(1-methylethyl)pyrimidine-5-carboxylate
BENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 2-chloro-4-ethylpyrimidine-5-carboxylate Ethyl 2-chloropyrimidine-5-carboxylate ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE ETHYL-2-CHLORO-4-METHYL-5-PYRIMIDINECARBOXYLATE
CYCLOPROPYLMETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-CHLOROBENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL 2-CHLORO-4-(N-ETHOXYCABONYLETHYL-N-ETHYLAMINO) PYRIMIDINE-5-CARBOXYLATE ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 4-tert-butyl-2-chloropyrimidine-5-carboxylate
ethyl 2,4-dichloropyrimidine-5-carboxylate
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Ethyl 2-chloropyrimidine-5-carboxylate ,97% 2-chloro-pyrimidine-5-carboxylic acid ethyl ester 2-Chloro-5-(ethoxycarbonyl)pyrimidine 5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester 2-Chloro-5-(ethoxycarbonyl)pyrimidine, 2-Chloro-5-(ethoxycarbonyl)-1,3-diazine Ethyl 2-Chlorpyrimidine-5-carboxylate 2-chloro-pyriMidine-5-carboxylate ETHYL2-CHLOROPYRIMI EOS-60350 5-Pyrimidinecarboxylic acid, 2-chloro-, ethyl ester (7CI, 9CI, ACI) 2-chloro-5-Pyrimidinecarboxylic acid ethyl ester (7CI 9CI ACI) 89793-12-4 Heterocycle-Pyrimidine series