Remdesivir N-2

CAS No.: 1191237-80-5

Chemical Name:: Remdesivir N-2

Synonyms: GS-5;Remdesivir-015;remdesivir N-2;NSJ-Remdesivir-RS009;Remdesivir Impurity 7;Remdesivir Intermediate 4;Remdesivir Intermediate 2;Remdesivir Related Compound 7;Remdesivir No. 5 Intermediate;Remdesivir O-desphosphate acetonide

CBNumber:: CB15493006

Molecular Formula:: C15H17N5O4

Molecular Weight:: 331.33

MOL File:: 1191237-80-5.mol

Modify Date:: 2024/7/2 8:55:01

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Remdesivir N-2 Properties

Density	1.66±0.1 g/cm3(Predicted)
solubility	DMSO:55.5(Max Conc. mg/mL);167.51(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);15.09(Max Conc. mM) PBS (pH 7.2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM) DMF:12.0(Max Conc. mg/mL);36.22(Max Conc. mM)
form	A solid
pka	14.14±0.10(Predicted)
color	Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

NFPA 704

	0
2		0

Remdesivir N-2 Chemical Properties,Uses,Production

Uses

Remdesivir N-2 can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in the research and development and chemical production of Remdesivir.

Synthesis

Synthesis_1191237-80-5
5.62g of compound GS-441524 was dissolved in 30mL of acetone, 11.50mL of 2,2-dimethoxypropane and 1.34mL of sulfuric acid were added, stirred at 45??C for half an hour, cooled to 25??C, and the organic solvent was removed by rotary evaporation. It was extracted with 100 mL of ethyl acetate and 100 mL of saturated sodium bicarbonate aqueous solution, and the extraction was repeated three times. The ethyl acetate layers were combined, dried by adding anhydrous sodium sulfate, and filtered to remove sodium sulfate. The organic solvent was removed by rotary evaporation, and column chromatography was performed (eluent: petroleum ether/ethyl acetate (V/V)=1/2) to obtain 6.20 g of compound 5 (white solid, 97% yield).

Remdesivir N-2 Preparation Products And Raw materials

Raw materials

GS-441524 D-Ribofuranose, 1-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,3,5-tris-O-(phenylmethyl)- (3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile Remdesivir impurity2 2,3,5-TRI-O-BENZYL-L-ARABINOFURANOSE

7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE 2,2-Dimethoxypropane

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Preparation Products

Remdesivir

Remdesivir N-2 Suppliers

Global( 103)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Syngenesis Chemscience Private Limited	08047301747	Pune, India	65	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29824	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	China	3878	58	Inquiry
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	China	431	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23555	58	Inquiry
Henan Alfa Chemical Co., Ltd	+8618339805032	China	13183	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Syngenesis Chemscience Private Limited	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Henan Alfa Chemical Co., Ltd	58

1191237-80-5(Remdesivir N-2)Related Search:

2-ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate Remdesivir Remdesivir impurity2 N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester Remdesivir-003-S

(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile Remdesivir Intermediate 4 Remdesivir Related Compound 7 Remdesivir-015 Remdesivir O-desphosphate acetonide impurity (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile (3Ar,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-4-carbonitrile Remdesivir No. 5 Intermediate (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydr NSJ-Remdesivir-RS009 (3ar, 4R, 6R, 6aR) - 4 - (4-aminopyrrole [1,2-f] [1,2,4] triazine-7-yl) - 6 - (hydroxymethyl) - 2,2-dimethyl-tetrahydrofuran [3,4-d] [1,3] dioxazole-4-nitrile 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE-D-ALTRONONITRILE 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-D-Altrononitrile D-ALTRONONITRILE, 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE (3aR,4R,6R,6aR)-4-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile (4R)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile Remdesivir Impurity 7 remdesivir N-2 GS-5 D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- D-Altrononitrile,2-C-(4-aminopyrrolo[2,1-f][1,2,4Chemicalbook]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- Remdesivir Intermediate 2 Remdesivir Acetonide Nitrile Impurity Remdesivir Impurity 7 (Remdesivir Acetonide Nitrile Impurity) Remdesivir O-desphosphate acetonide 1191237-80-5 PEG