CalciuM polycarbophil
- CAS No.
- 9003-97-8
- Chemical Name:
- CalciuM polycarbophil
- Synonyms
- Polycarbophil;CL272;Carbofil;CARBOPOLEX55;Polycarbofil;Policarbofila;Polycarbofil calcico;CALCIUM POLYCARBOPHIL;polycarbophil calcium;Donepezil Impurity 54
- CBNumber:
- CB21011948
- Molecular Formula:
- (C20H18Ca4O18)mult
- Molecular Weight:
- 0
- MOL File:
- Mol file
- Modify Date:
- 2024/7/2 8:55:01
| solubility | Polycarbophil polymers do not dissolve in water but can swell in water to around 1000 times their original volume (and ten times their original diameter) to form gels when exposed to a pH environment above 4–6. Since the pKa of these polymers is 6.0±0.5, the carboxylate groups on the polymer backbone ionize, resulting in electrostatic repulsion between the negative particles, which extends the molecule, adding to the swelling of the polymer. |
|---|---|
| form | Solid |
| color | White to off-white |
CalciuM polycarbophil Chemical Properties,Uses,Production
Chemical Properties
Polycarbophil occurs as fluffy, white to off-white, mildly acidic polymer powder with slightly acetic odor.
Uses
Benzodiazepine anxiolytic
Production Methods
Polycarbophils are synthetic, high-molecular-weight, crosslinked polymers of acrylic acid. These poly(acrylic acid) polymers are crosslinked with divinyl glycol. They are synthesized via precipitation polymerization in ethyl acetate and then dried.
Safety
Polycarbophil polymers have a long history of safe and effective use
in topical gels, creams, lotions, and ointments. They have been
shown to have extremely low irritancy properties and are
nonsensitizing with repeated usage.
The use of these polymers is supported by extensive toxicological
studies.
(guinea pig, oral): 2.0 g/kg
(mouse, IP): 0.039 g/kg
(mouse, IV): 0.070 g/kg
(mouse, oral): 4.6 g/kg
(rat, oral): >2.5 g/kg
(rabbit, skin): >3.0 g/kg
Chronic oral toxicity No significant effects in rats or dogs were
observed after being fed with resin as 5% of the diet for 6?
months.
storage
Polycarbophil polymers are stable, hygroscopic materials. They do
not undergo hydrolysis or oxidation under normal conditions. Heat
aging at temperatures below 104°C for up to 2 hours does not affect
the efficiency of the dry polymer. However, prolonged exposure to
excessive temperatures can result in discoloration, reduced stability,
and in some cases plasticization of the polymer. Complete
decomposition occurs with heating for 30 minutes at 260°C.
Polycarbophil polymers do not support bacteria, mold, or fungal
growth in dry powder form. Microbial growth may occur in
mucilages of the polymer solution. Although the gel properties are
not affected by such growth, this phenomenon is usually
unacceptable. The addition of appropriate preservatives prevents
mold and bacterial growth in these mucilages. Mucilages and
emulsions containing these polymers are stable under freeze–thaw
conditions but exposure to high temperatures results in a drop in
viscosity.
Polycarbophil polymers are very hygroscopic and should be
packed in airtight, corrosion-resistant containers. They should be
stored in a cool, dry place, and the container should be kept closed
when not in use. Moisture pickup does not affect the efficiency of
the resins, but resin containing high levels of moisture is more
difficult to disperse and weigh accurately. Glass, plastic, or resinlined
containers are recommended for products containing polycarbophil.
Packaging in aluminum tubes usually requires formulations
to have a pH less than 6.5, and packaging in other metallic
tubes or containers necessitates a pH greater than 7.7 to prolong
polycarbophil stability.
Incompatibilities
Heat may be generated if polycarbophil comes into contact with strong basic materials such as ammonia, sodium hydroxide, potassium hydroxide, or strongly basic amines. Polycarbophil polymers are not compatible with cationic polymers, strong acids, and high levels of electrolytes, as electrolytes tend to reduce the viscosity of polycarbophil-based gels.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (buccal (tablet) and ophthalmic (solution) preparations; topical patches; vaginal gel). Included in nonparenteral medicines licensed in the UK.
CalciuM polycarbophil Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Arihant Innochem Private Limited | 08066085977Ext 288 | Mumbai, India | 2 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12453 | 58 | Inquiry |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | China | 990 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | China | 2989 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | China | 8822 | 58 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
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