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BAY 2666605

BAY 2666605 Structure
CAS No.
2275774-60-0
Chemical Name:
BAY 2666605
Synonyms
BAY 266605;BAY 2666605;(S)-5-[4’-Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one;(S)-5-[4’-Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one;2H-1,3,4-Oxadiazin-2-one, 5-[4'-fluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-6-methyl-, (6S)-;anticancer effect,inhibit,BAY 2666605,orally active,PDE3A-SLFN12 Complex,Phosphodiesterase (PDE),BAY2666605,BAY-2666605,Inhibitor
CBNumber:
CB210828953
Molecular Formula:
C17H12F4N2O2
Molecular Weight:
352.28
MOL File:
2275774-60-0.mol
Modify Date:
2024/7/2 8:55:01
Request For Quotation

BAY 2666605 Properties

Density 1.40±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 9.07±0.60(Predicted)
color White to off-white
InChI InChI=1S/C17H12F4N2O2/c1-9-15(22-23-16(24)25-9)11-4-7-13(14(8-11)17(19,20)21)10-2-5-12(18)6-3-10/h2-9H,1H3,(H,23,24)/t9-/m0/s1
InChIKey JNTJTCXFIXNXDV-VIFPVBQESA-N
SMILES O1[C@@H](C)C(C2=CC=C(C3=CC=C(F)C=C3)C(C(F)(F)F)=C2)=NNC1=O

BAY 2666605 Chemical Properties,Uses,Production

Uses

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer.

in vitro

BAY 2666605 has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer.

BAY 2666605 Preparation Products And Raw materials

Raw materials

Preparation Products

BAY 2666605 Suppliers

Global( 18)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
SUZHOU SENFEIDA CHEMICAL CO.,LTD +86-0512-83500002 +8615195660023 China 23048 58 Inquiry
Guangzhou Younan Technology Co., Ltd 020-020-82000279 18988968278 China 4297 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9268 58 Inquiry
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 China 10313 58 Inquiry
Chengdu DingDang Pharmaceutical Co., Ltd. 028-86040038 13980902949; China 1846 55 Inquiry
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 China 3466 58 Inquiry
Nantong Hi-Future Biotechnology Co., Ltd 18051384581 China 3058 58 Inquiry
Supplier Advantage
Nantong HI-FUTURE Biology Co., Ltd. 58
Aladdin Scientific 58
ATK CHEMICAL COMPANY LIMITED 60
SUZHOU SENFEIDA CHEMICAL CO.,LTD 58
Guangzhou Younan Technology Co., Ltd 58
RD International Technology Co., Limited 58
Accela ChemBio Co.,Ltd. 58
Chengdu DingDang Pharmaceutical Co., Ltd. 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Nantong Hi-Future Biotechnology Co., Ltd 58

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BAY 2666605 anticancer effect,inhibit,BAY 2666605,orally active,PDE3A-SLFN12 Complex,Phosphodiesterase (PDE),BAY2666605,BAY-2666605,Inhibitor 2H-1,3,4-Oxadiazin-2-one, 5-[4'-fluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-6-methyl-, (6S)- BAY 266605 (S)-5-[4’-Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one (S)-5-[4’-Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one 2275774-60-0