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DL-TBOA

DL-TBOA Structure
CAS No.
205309-81-5
Chemical Name:
DL-TBOA
Synonyms
DL-TBOA;DLTBOA,DL TBOA;BYOBCYXURWDEDS-IUCAKERBSA-N;D,L-THREO-B-BENZYLOXYASPARTATE;DL-threo-β-Benzyloxyasparticacid;DL-THREO-BETA-BENZYLOXYASPARTIC ACID;D-Aspartic acid, 3-(phenylmethoxy)-, (3R)-rel-
CBNumber:
CB2208679
Molecular Formula:
C11H13NO5
Molecular Weight:
239.22
MOL File:
Mol file
Modify Date:
2025/4/17 18:22:24
Request For Quotation

DL-TBOA Properties

Boiling point 421.7±45.0 °C(Predicted)
Density 1.392±0.06 g/cm3(Predicted)
storage temp. Desiccate at -20°C
solubility <23.92mg/ml in DMSO;insoluble in H2O
form solid
pka 2.07±0.27(Predicted)
color White

DL-TBOA Chemical Properties,Uses,Production

Description

DL-TBOA is an inhibitor of excitatory amino acid transporters (EAATs), with IC50 values of 67 and 5.5 μM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively. It inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 μM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 3.2 μM) voltage-clamped at -60 mV. In vivo, DL-TBOA (500 μM, intrahippocampal perfusion) increases extracellular aspartate, glutamate, and alanine levels in rat hippocampus. Intrahippocampal injection of DL-TBOA increases lesion volume in the rat CA1 region in a dose-dependent manner and induces hyperexcitability, wet-dog shakes, salivation, forelimb myoclonus, limbic seizures, and epileptic EEG discharges at a dose of 25 nmol. DL-TBOA (5 and 10 μg, intrathecal) induces antinociception in the second phase of the formalin test in rats when administered 10 minutes prior to formalin.

Uses

DL-TBOA is a non-transportable excitatory amino acid transporter (EAAT) inhibitor (1). DL-TBOA is a glutamate uptake inhibitor.

DL-TBOA Preparation Products And Raw materials

Raw materials

Preparation Products

DL-TBOA Suppliers

Global( 42)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32202 58 Inquiry
Aladdin Scientific United States 52924 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9835 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24683 58 Inquiry
4008-099-669 CHINA 73043 58 Inquiry
Neobioscience Co., Ltd. 4006-800-892 CHINA 6207 58 Inquiry
R&D Systems, Inc 18003437475 18003437475 China 35960 58 Inquiry
Cayman Chemical Company 800-364-9897 China 27736 58 Inquiry
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 China 233051 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6213 81 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
58
Neobioscience Co., Ltd. 58
R&D Systems, Inc 58
Cayman Chemical Company 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
Cayman Chemical Company 81
DL-THREO-BETA-BENZYLOXYASPARTIC ACID D,L-THREO-B-BENZYLOXYASPARTATE DL-TBOA DL-threo-β-Benzyloxyasparticacid D-Aspartic acid, 3-(phenylmethoxy)-, (3R)-rel- BYOBCYXURWDEDS-IUCAKERBSA-N DLTBOA,DL TBOA 205309-81-5