Isosorbide dinitrate
- CAS No.
- 87-33-2
- Chemical Name:
- Isosorbide dinitrate
- Synonyms
- ISDN;isordil;sorbide;carvasin;sorbitrate;Lion's Mane;dilatrate-sr;Isosorbide dinitrate CRS;(3R,3aS,6S,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate;cardis
- CBNumber:
- CB2226929
- Molecular Formula:
- C6H8N2O8
- Molecular Weight:
- 236.14
- MOL File:
- 87-33-2.mol
- Modify Date:
- 2024/7/2 8:55:03
| Melting point | 700C |
|---|---|
| alpha | D20 +135° (alc) |
| Boiling point | 378.59°C (rough estimate) |
| Density | 1.7503 (rough estimate) |
| refractive index | 1.5010 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Undiluted isosorbide dinitrate is very slightly soluble in water, very soluble in acetone, sparingly soluble in ethanol (96 per cent). The solubility of the diluted product depends on the diluent and its concentration. |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 549.7mg/L(25 ºC) |
| BCS Class | 3 |
| InChIKey | MOYKHGMNXAOIAT-JGWLITMVSA-N |
| LogP | 1.31 at 25℃ |
| CAS DataBase Reference | 87-33-2(CAS DataBase Reference) |
| EPA Substance Registry System | D-Glucitol, 1,4:3,6-dianhydro-, dinitrate (87-33-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H207-H302 | |||||||||
| Precautionary statements | P210-P212-P230-P233-P280-P370+P380+P375-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 5-22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | UN 2907 | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2932999000 | |||||||||
| Toxicity | LD50 oral in rat: 747mg/kg | |||||||||
| NFPA 704 |
|
Isosorbide dinitrate Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powde
Uses
Isosorbide dinitrate is also used in chronic cardiac insufficiency for preventing angina pectoris attacks. It is a long-lasting drug.
General Description
A crystalline solid. May be toxic by ingestion. Used to make pharmaceuticals. Used as a heart drug.
Air & Water Reactions
Highly flammable. Slightly soluble in water.
Reactivity Profile
Nitroalkanes, such as Isosorbide dinitrate, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. Nitroalkanes are milder oxidizing agents, but still react violently with reducing agents at higher temperature and pressures. Nitroalkanes react with inorganic bases to form explosive salts. The presence of metal oxides increases the thermal sensitivity of nitroalkanes. Nitroalkanes with more than one nitro group are generally explosive. Nitroalkanes are insoluble in water. This heart drug is detonable when dry, but non-explosive with 30% of water.
Health Hazard
Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.
Safety Profile
Moderately toxic by ingestion, intraperitoneal, intramuscular, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. A flammable solid. When heated to decomposition it emits toxic fumes of NOx. A coronary vasodilator. See also NITRATES.
Isosorbide dinitrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| J P Laboratory Pvt Ltd | +91-2027123137 +91-9860798093 | Maharashtra, India | 2 | 58 | Inquiry |
| Innova Pharmactive Pvt. Ltd | +91-7122649427 +91-7122649427 | Mumbai, India | 9 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Healthy Life Pharma Private Limited | 08048372782Ext 850 | Mumbai, India | 19 | 58 | Inquiry |
| Rani Chennamma COP | 09542185209 | Karnataka, India | 3 | 58 | Inquiry |
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