Amiodarone-D4 HCl
- CAS No.
- 1216715-80-8
- Chemical Name:
- Amiodarone-D4 HCl
- Synonyms
- Prosulfocarb Impurity 3-d10;Amiodarone hydrochloride salt;[2H4]-Amiodarone Hydrochloride;2H4]-Amiodarone hydrochloride salt;Amiodarone-D4 hydrochloride solution;AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE);(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride;Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride
- CBNumber:
- CB22560799
- Molecular Formula:
- C25H30ClI2NO3
- Molecular Weight:
- 681.78
- MOL File:
- 1216715-80-8.mol
- Modify Date:
- 2024/7/2 8:55:03
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310-P311 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
Amiodarone-D4 HCl Chemical Properties,Uses,Production
Description
Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.
General Description
A Certified Spiking Solution?and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone?, Cordarone?, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range.
Amiodarone-D4 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
Amiodarone-D4 HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | China | 18488 | 58 | Inquiry |
| Cerilliant Corporation | 800 848 7837 (US and Canada) | United States | 1638 | 69 | Inquiry |
| Toronto Research Chemicals | +1 (416) 665-9696 | Canada | 6088 | 71 | Inquiry |
| Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
| Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 02584622273; | China | 3022 | 58 | Inquiry |
| Shanghai Hao Zhun Biological Technology Co., Ltd. | 15800340161 | CHINA | 6846 | 58 | Inquiry |
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