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Citarinostat

Citarinostat Structure
CAS No.
1316215-12-9
Chemical Name:
Citarinostat
Synonyms
CS-1760;HDAC-IN-2;Citarinostat;ACY-241(CITARINOSTAT);Citarinostat (ACY-241);Citarinostat(ACY-241,HDAC-IN-2);ACY-241; ACY 241; ACY241; HDAC-IN-2; CITARINOSTAT.;2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-;2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide
CBNumber:
CB22723105
Molecular Formula:
C24H26ClN5O3
Molecular Weight:
467.95
MOL File:
1316215-12-9.mol
Modify Date:
2024/7/2 8:55:03
Request For Quotation

Citarinostat Properties

Density 1.293±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥23.4 mg/mL in DMSO; insoluble in H2O; ≥4.87 mg/mL in EtOH with ultrasonic
form solid
pka 9.47±0.20(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

Citarinostat Chemical Properties,Uses,Production

Description

ACY-241 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 2.6 nM). It is selective for HDAC6 over HDAC1-3, HDAC7, and HDAC9 (IC50s = 35, 45, 46, 7,300, and 137 nM, respectively), as well as HDAC4, HDAC5, and HDAC9 (IC50 = >20,000 nM for all). It reduces proliferation of A2780, TOV-21G, and MDA-MB-231 cells when used at a concentration of 3 μM and completely inhibits it and induces apoptosis at a concentration of 10 μM. ACY-241, when used in combination with paclitaxel , inhibits proliferation in MiaPaCa-2, TOV-21G, and T47D cells. It also reduces tumor growth in a MiaPaCa-2 mouse xenograft model when administered at a dose of 50 mg/kg in combination with paclitaxel. ACY-241, in combination with the somatostatin receptor agonist pasireotide , reduces hepatorenal cystogenesis in a rat model of polycystic liver disease.

Citarinostat Preparation Products And Raw materials

Raw materials

Preparation Products

Citarinostat Suppliers

Global( 93)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418684 +8618949823763 China 25363 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Pharma Affiliates 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
LEAP CHEM CO., LTD. 58
TargetMol Chemicals Inc. 58

Citarinostat Spectrum

Citarinostat(1316215-12-9)1HNMR

1316215-12-9(Citarinostat)Related Search:

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2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide Citarinostat Citarinostat (ACY-241) ACY-241(CITARINOSTAT) 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide 5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]- HDAC-IN-2 Citarinostat(ACY-241,HDAC-IN-2) (Z)-2-((2-chlorophenyl)(phenyl)amino)-N-((Z)-7-hydroxy-7-(hydroxyimino)heptyl)pyrimidine-5-carbimidic acid (Z)-2-((2-CHLOROPHENYL)(PHENYL)AMINO)-N-((Z)-7-HYDROXY-7-(HYDROXYIMINO)HEPTYL)PYRIMIDINE-5-CARBIMIDIC ACID;HDAC-IN-2 CS-1760 ACY-241; ACY 241; ACY241; HDAC-IN-2; CITARINOSTAT. N-(6-(hydroxycarbamoyl)hexyl)-2-(N-(2-chlorophenyl)-N-phenylamino)pyrimidine-5-carboxamide 1316215-12-9