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DM4

CAS No.: 796073-69-3

Chemical Name:: DM4

Synonyms: Ravtansine;The element DM4;Mertansine Impurity 1;DM4,Ravtansine/soravtansine;DM4 top3;Benzoicacid,5-(chlorosulfonyl)-4-methyl-;N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine;N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine;Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-;N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4)

CBNumber:: CB23040339

Molecular Formula:: C38H54ClN3O10S

Molecular Weight:: 780.37

MOL File:: 796073-69-3.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:03

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DM4 Properties

Melting point	185-187 °C (decomp)
Boiling point	943.2±65.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (128.14 mM)
form	Solid
pka	9.82±0.70(Predicted)
color	White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS05,GHS06
Signal word	Danger
Hazard statements	H370-H360-H314-H340-H310-H300
Precautionary statements	P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501

DM4 Chemical Properties,Uses,Production

Description

Ravtansine (DM4) is a maytansinoid, a chemical derivative of maytansine being investigated as the cytotoxic payload of a number of antibody-drug conjugates (ADCs).M4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.

Uses

N2''-Deacetyl-N2''-(4-mercapto-4-methyl-1-oxopentyl)-maytansine is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.

Biological Activity

The anticancer properties of maytansinoids have been attributed to their ability to disrupt microtubule function. The maytansinoid emtansine (DM1), for example, binds at the ends of microtubules and thereby suppress their dynamic instability. Other maytansinoids include: Ansamitocin; Mertansine/emtansine (DM1); Ravtansine/soravtansine (DM4).

References

[1] Giulio Lovato . “HPLC-DAD validated method for DM4 and its metabolite S-Me-DM4 quantification in biological matrix for clinical and pharmaceutical applications.” Journal of pharmaceutical and biomedical analysis 235 (2023): Article 115642.

DM4 Preparation Products And Raw materials

Raw materials

Pentanenitrile, 4-mercapto-4-methyl- L-Alanine, N-methyl-N-[4-methyl-4-(methyldithio)-1-oxopentyl]- Pentanoic acid, 4-methyl-4-(methyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester DM4-Sme Maytansinol

Preparation Products

DM4 Suppliers

Global( 125)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Shanghai Minbiotech Co., Ltd.	+8617315815539	CHINA	129	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9337	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	China	5738	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Shanghai Minbiotech Co., Ltd.	58
Fuxin Pharmaceutical	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58

DM4:Activity and Preparation
The DM4, as the cytotoxic agent refering to a substance that inhibits or prevents one or more cellular functions or causes cel....
Mar 10，2023

796073-69-3(DM4)Related Search:

Mertansine Glycine, N-(4-cyanophenyl)-, ethyl ester

N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)- DM4 top3 Mertansine Impurity 1 N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4) The element DM4 Benzoicacid,5-(chlorosulfonyl)-4-methyl- Ravtansine DM4,Ravtansine/soravtansine Microtubule/Tubulin,Inhibitor,DM4,inhibit,ADC Payload,DM 4,ADC Cytotoxin,DM-4 (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-(4-mercapto-4-methylpentanoyl)-N-methyl-L-alaninate N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4) N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine 796073-69-3 C38H54ClN3O10S

DM4