RO 15-4513
![RO 15-4513 Structure](CAS/GIF/91917-65-6.gif)
- CAS No.
- 91917-65-6
- Chemical Name:
- RO 15-4513
- Synonyms
- RO 15-4513;Azidomazenil;Ro15 4513,Ro154513,Ro-15-4513;RO 15-4513 ETHANOL ANTAGONIST;Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate;ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE;8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester;8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER;4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
- CBNumber:
- CB2312745
- Molecular Formula:
- C15H14N6O3
- Molecular Weight:
- 326.32
- MOL File:
- 91917-65-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
storage temp. | Desiccate at +4°C |
---|---|
solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL |
form | solid |
color | tan |
CAS DataBase Reference | 91917-65-6 |
RO 15-4513 price More Price(2)
RO 15-4513 Chemical Properties,Uses,Production
Description
Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro 15-4513's Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Ro 15-4513 displays partial agonism at DI α4- and α6-GABAA receptors.
Chemical Properties
Off-white solid
Uses
Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.
Application
Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.
Biological Activity
High affinity benzodiazepine ligand. K i values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α 1-, α 2-, α 3- and α 5-GABA A receptors. Displays partial agonism at DI α 4- and α 6-GABA A receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
RO 15-4513 Preparation Products And Raw materials
Raw materials
Preparation Products
RO 15-4513 Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
RD International Technology Co., Limited | 18024082417 | China | 9155 | 58 | Inquiry |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | China | 4399 | 58 | Inquiry |
DC Chemicals | 021-58447131 13564518121 | China | 9412 | 58 | Inquiry |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | China | 15848 | 69 | Inquiry |
Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
BIOTREND Chemicals AG | +41 44 805 76 76 | Germany | 1250 | 62 | Inquiry |
Service Chemical Inc. | 888-895-6920 | Germany | 6373 | 71 | Inquiry |
91917-65-6(RO 15-4513)Related Search:
1of4
chevron_right