AMG 510
- CAS No.
- 2252403-56-6
- Chemical Name:
- AMG 510
- Synonyms
- CPD2809;4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one;Sotorasib (AMG-510);Sotorasib (racemate);Sotorasib (AMG-510) racemate;Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-;AMG 510;(S)-AMG-510;AMG-510，AMG510;Amg 510 Powder
- CBNumber:
- CB24858719
- Molecular Formula:
- C30H30F2N6O3
- Molecular Weight:
- 560.59
- MOL File:
- 2252403-56-6.mol
- Modify Date:
- 2024/7/2 8:55:03
| Boiling point | 730.5±70.0 °C(Predicted) |
|---|---|
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C, stored under nitrogen |
| solubility |
DMSO:75.0(Max Conc. mg/mL);133.78(Max Conc. mM) Water:33.33(Max Conc. mg/mL);59.45(Max Conc. mM) Ethanol:8.0(Max Conc. mg/mL);14.27(Max Conc. mM) |
| form | Solid |
| pka | 6.52±0.35(Predicted) |
| color | Light yellow to yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
AMG 510 Chemical Properties,Uses,Production
Uses
AMG-510 is a KRAS G12C inhibitor thus leading to the regression of KRAS G12C tumors as it interrupts protein signaling.
in vitro
It was examined whether AMG510 has an antitumor effect on the CACO-2 (human colorectal cancer) cells into which the KRAS G12C (Kirsten rat sarcoma 2 viral oncogene homolog mutation) gene was introduced. The results showed that there was a clear concentration dependent RPR (relative proliferation ratio) decrease and that AMG 510 selectively inhibited KRAS G12C in colon cancer cells in vitro (Fig. 4A). Reference: Mol Clin Oncol. 2021 Jul;15(1):148.
AMG 510 Preparation Products And Raw materials
Raw materials
Preparation Products
AMG 510 Suppliers
Global( 142)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| Beijing Mesochem Technology Co.,Ltd | +8613651027935 | China | 191 | 58 | Inquiry |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | China | 289 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7621 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7192 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23555 | 58 | Inquiry |
6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-[4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL]-4-[(2S)-2-METHYL-4-(P
6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]-1H,2H-pyrido[2,3-d]pyrimidin-2-one
AMG-510;AMG 510;AMG510
AMG 510
chiral AMG 510, single isomer
AMG-510，AMG510
AMG-510 atropisomer
AMG 510 USP/EP/BP
4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
CPD2809
Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-
Sotorasib (AMG-510)
Sotorasib (racemate)
Sotorasib (AMG-510) racemate
Amg 510 Powder
Ras,inhibit,AMG 510,Sotorasib racemate,Inhibitor,AMG-510,Sotorasib,AMG510
6-fluoro-7-(2-fluoro-6-hydroxy-phenyl)-1-(2-isopropyl-4-methyl-3-pyridyl)-4-[(2S)-2-methyl-4-prop-2-enoyl-piperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
Cinoxacin Impurity 4
(S)-AMG-510
2252403-56-6
252403-56-6
225240-56-6
GS