PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM
- CAS No.
- 724709-68-6
- Chemical Name:
- PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM
- Synonyms
- PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM;4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one;7H-Furo[3,2-g][1]benzopyran-7-one, 4-(4-phenylbutoxy)-
- CBNumber:
- CB2973067
- Molecular Formula:
- C21H18O4
- Molecular Weight:
- 334.37
- MOL File:
- 724709-68-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H413 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Chemical Properties,Uses,Production
Description
Psora 4 is an inhibitor of voltage-gated potassium channels (Kv1.3; EC50 = 3 nM). It is selective for Kv1.3 over Kv1.1, Kv1.2, Kv1.4, Kv1.7, and Kv3.1 channels (EC50s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the Kv1.5 channel (EC50 = 7.7 nM). Psora 4 selectively binds to the C-type inactivated state of the Kv1.3 channel and inhibits potassium current in a use-dependent manner. It has immunosuppressive activity, inhibiting proliferation of human and rat myelin-specific effector memory T cells in vitro (TEM cells; EC50s = 25 and 60 nM, respectively).
Uses
Psora-4 is the most potent small-molecule Kv1.3 blocker known. Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disorders.
Biochem/physiol Actions
The lymphocyte potassium channel Kv1.3 is regarded as a new target for immunosuppression. Psora-4 is the most potent small-molecule Kv1.3 blocker known. It blocked Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC50 value of 3 nM, by preferentially binding to the C-type inactivated state of the channel. It exhibited 17- to 70-fold selectivity for Kv1.3 over closely related Kv1-family channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7) with the exception of Kv1.5 (EC50, 7.7 nM) and showed no effect on human ether-a-go-go-related channel, Kv3.1, the calcium-activated K+ channels (IKCa1, SK1-SK3, and BKCa), or the neuronal NaV1.2 channel. In a test of in vivo toxicity in rats, Psora-4 did not display any signs of acute toxicity after five daily subcutaneous injections at 33 mg/kg body weight. Psora-4 selectively suppressed the proliferation of human and rat myelin-specific effector memory T cells with EC50 values of 25 and 60 nM, respectively, without persistently suppressing peripheral blood naive and central memory T cells. Because autoantigen-specific effector memory T cells contribute to the pathogenesis of T cell-mediated autoimmune diseases such as multiple sclerosis, Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disord.
PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
PHENOLPHTHALEIN DIPHOSPHATE TETRASODIUM Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8141 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 23963 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8739 | 58 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry | |
| DC Chemicals | 021-58447131 13564518121 | China | 9412 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9274 | 58 | Inquiry |
| InvivoChem | 13549236410 | China | 6747 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| InvivoChem | 58 |
| MedBioPharmaceutical Technology Inc | 58 |
| TargetMol Chemicals Inc. | 58 |
| Cayman Chemical Company | 81 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| BOC Sciences | 65 |
| DC Chemicals | 58 |
| RD International Technology Co., Limited | 58 |
| InvivoChem | 58 |