Sodium 4-Aminophenylarsonate
- CAS No.
- 127-85-5
- Chemical Name:
- Sodium 4-Aminophenylarsonate
- Synonyms
- soamin;sonate;ATOXYL;arsamin;nuarsol;protoxyl;trypoxyl;nci-c61176;Chebi:36049;arsinosolvin
- CBNumber:
- CB3111606
- Molecular Formula:
- C6H6AsNNa2O3
- Molecular Weight:
- 261.02
- MOL File:
- 127-85-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 17:06:37
| Water Solubility | Soluble in water |
|---|---|
| form | powder to crystal |
| color | Tetrahydrate: white, crystalline powder |
| Odor | odorless |
| Merck | 14,8578 |
| EPA Substance Registry System | Sodium arsanilate (127-85-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS08,GHS09,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H410-H400-H331-H350-H301 | |||||||||
| Precautionary statements | P273-P391-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P273-P391-P501-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| Risk Statements | 26/27/28 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | 2473 | |||||||||
| RTECS | CF9625000 | |||||||||
| HS Code | 2920.90.2000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | LD50 scu-rat: 75 mg/kg BIZEA2 184,360,27 | |||||||||
| NFPA 704 |
|
Sodium 4-Aminophenylarsonate Chemical Properties,Uses,Production
General Description
A white crystalline, odorless powder. Slightly denser than water. Contact may irritate skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals.
Air & Water Reactions
Soluble in water.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Pharmaceutical Applications
Bechamp,teaching medicinal chemistry at the University of Montpellier, synthesised in 1863 a compound from aniline and arsenic acid, which became known later as Atoxyl. The name Atoxyl stems from its decreased toxicity. Bechamp characterised his compound as an anilide.
In 1905, Thomas and Breinl showed that Atoxyl was effective in the treatment of trypanosomas, mainly Trypanosoma brucei gambiense-the cause of the African sleeping sickness, which was the main health problem around that time in Africa. Nevertheless, very high doses were required to show any pronounced effect, and as a result severe side effects such as blindness and damage to the optical nerve were common issues.
Inspired by this research, Ehrlich hired the chemist Bertheim in 1905. Bertheim revised the structure of Atoxyl and the correct chemical formula was assigned. Atoxyl was identified as an p-anilinyl arsenic acid derivative on the basis of its properties to reduce Tollen’s reagent [Ag(NH3)2]+ to metallic silver and its potential use to synthesise the corresponding diazo dye.
Safety Profile
Poison by subcutaneous route. Can cause blindness. When heated to decomposition it emits very toxic fumes of As and NOx.
Sodium 4-Aminophenylarsonate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16923 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24607 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | China | 23053 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| ABCR GmbH & CO. KG | 49 721 95061 0 | Germany | 6846 | 75 | Inquiry |
| VWR International, LLC. | 1-610-3861700 | United States | 6265 | 58 | Inquiry |