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4-Aminopyrazolo[3,4-d]pyrimidine

CAS No.: 2380-63-4

Chemical Name:: 4-Aminopyrazolo[3,4-d]pyrimidine

Synonyms: 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;4-app;4 APP;nsc1393;NSC 1393;4-Aminopyra;Aminopurinol;Pyrazoloadenine;TIMTEC-BB SBB004205;ADENINE ANTIMETABOLITE

CBNumber:: CB3112436

Molecular Formula:: C5H5N5

Molecular Weight:: 135.13

MOL File:: 2380-63-4.mol

Modify Date:: 2024/4/9 22:15:29

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4-Aminopyrazolo[3,4-d]pyrimidine Properties

Melting point	>325 °C(lit.)
Boiling point	238.81°C (rough estimate)
Density	1.3795 (rough estimate)
refractive index	1.7000 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in DMSO
form	powder to crystal
pka	12.12±0.20(Predicted)
color	White to Orange to Green
Water Solubility	Insoluble in water.
BRN	5824
InChIKey	LHCPRYRLDOSKHK-UHFFFAOYSA-N
CAS DataBase Reference	2380-63-4(CAS DataBase Reference)
NIST Chemistry Reference	1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
EPA Substance Registry System	1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS07

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501-P301+P310a-P321-P501a-P261-P301+P310-P305+P351+P338

Hazard Codes

Risk Statements

25-36/37/38-23/24/25

Safety Statements

26-36/37/39-45-22-36

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

UR0717000

TSCA

Yes

HazardClass

6.1

PackingGroup

III

HS Code

29335990

Toxicity

LD50 oral in rat: 141mg/kg

NFPA 704

	0
3		0

4-Aminopyrazolo[3,4-d]pyrimidine price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	A1041	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	100MG	₹2000	2022-05-26	Buy
TCI Chemicals (India)	A1041	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	1G	₹2600	2022-05-26	Buy
TCI Chemicals (India)	A1041	4-Aminopyrazolo[3,4-d]pyrimidine	2380-63-4	5G	₹8800	2022-05-26	Buy

Product number	Packaging	Price	Buy
A1041	100MG	₹2000	Buy
A1041	1G	₹2600	Buy
A1041	5G	₹8800	Buy

4-Aminopyrazolo[3,4-d]pyrimidine Chemical Properties,Uses,Production

Description

4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].

Chemical Properties

Light Tan Solid

Uses

4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.

References

[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.

4-Aminopyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine

4-Aminopyrazolo[3,4-d]pyrimidine Suppliers

Global( 413)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.R. LIFE SCIENCES PVT. LTD.	+91-914040267679 +91-8519993257	Hyderabad, India	100	58	Inquiry
SVH BIOSCIENCES	+91-6303499280 +91-6303499280	Hyderabad, India	478	58	Inquiry
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Ganapa Liife Science	+91 7760536535	Bangalore, India	168	58	Inquiry
Sapala Organics Private Limited	+91-4027170174 +91-9963110948	Telangana, India	89	58	Inquiry
Stereokem Pvt Ltd	+91-4029706929 +91-9394224843	Telangana, India	350	58	Inquiry
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Trimax bio sciences private ltd	+91-8532299988 +91-8532299988	Karnataka, India	36	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry

Supplier	Advantage
A.R. LIFE SCIENCES PVT. LTD.	58
SVH BIOSCIENCES	58
PRODIGIOUS LIFE SCIENCES	58
Ganapa Liife Science	58
Sapala Organics Private Limited	58
Stereokem Pvt Ltd	58
Aravali Pharma And Lifesciences	58
Trimax bio sciences private ltd	58
TCI Chemicals (India) Pvt. Ltd.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58

4-Aminopyrazolo[3,4-d]pyrimidine Spectrum

4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)¹HNMR 4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)Raman 4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4)IR

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TIMTEC-BB SBB004205 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE 4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE ADENINE ANTIMETABOLITE 4- aMinopyrazolo [3,4-d] pyriMidines PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-Amino-1H-pyrazolo[3,4-d]pyrimidine,98% 1(H)-4-amine-pyrazolo[3,4-d]pyrimidine 1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine 4-Aminopyrazolo[3,4-d]pyrimidine 98% 1H-pyrazolo[4,3-e]pyrimidin-4-amine 1H-pyrazolo[4,3-e]pyrimidin-4-ylamine 4-Aminopyrazolo[3,4-d]pyrimidine 4-Aminopyra 1H-Pyrazolo[3,4-d]pyrimidine, 4-amino- 4 APP 4-Aminopyrazole(3,4-d)pyrimidine 4-Aminopyrazolopyrimidine 4-d)pyrimidine,4-amino-1h-pyrazolo( NSC 1393 nsc1393 Pyrazoloadenine 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI) Adenine antimetabolite, Pyrazolo[3,4-d]pyrimidin-4-amin Aminopurinol 4-Amino-1,2,5,7-tetraaza-1H-indene 4-Aminopyrazolo[3,4-d]pyrimidine,98% 4-AMinopyrazolo[3,4-d]pyriMidine, 97.5% Pyrazolo[3,4-d]pyrimidin-4-amin 4-Aminopyrazolo[3,4-d]pyrimidine > 4-Dihydroxybenzylamine hydrobromide 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-app 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI, ACI) 4-aminopyrazole and [3,4-d] pyrimidine IbrutinibIntermediate5 2380-63-4 Building Blocks Heterocyclic Building Blocks Pyrimidines Heterocyclic Compounds Heterocycles PYRIMIDINE Pyridines, Pyrimidines, Purines and Pteredines Heterocycle-Pyrimidine series