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4-Chloro-4'-fluorobutyrophenone

CAS No.: 3874-54-2

Chemical Name:: 4-Chloro-4'-fluorobutyrophenone

Synonyms: 4-CHLORO-4-FLUOROBUTYROPHENONE;NSC 87082;LUMAT-009;JACS-3874-54-2;AKOS BBS-00006481;uorobutyrophenone;TIMTEC-BB SBB003536;4-Chloro-4'-fluorobu;Haloperidol Impurity 1;Haloperidol Impurity 21

CBNumber:: CB3118281

Molecular Formula:: C10H10ClFO

Molecular Weight:: 200.64

MOL File:: 3874-54-2.mol

MSDS File:: SDS

Modify Date:: 2024/9/2 11:34:00

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4-Chloro-4'-fluorobutyrophenone Properties

Melting point	5-6 °C
Boiling point	130-132 °C (0.97513 mmHg)
Density	1.22 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5255(lit.)
Flash point	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Oil
color	Slightly yellow-greenish clear
PH	4.05 at 23.1℃ and 10g/L
Water Solubility	0.38 g/L (20 ºC)
BRN	608741
InChIKey	HXAOUYGZEOZTJO-UHFFFAOYSA-N
LogP	2.84 at 30℃
CAS DataBase Reference	3874-54-2(CAS DataBase Reference)
NIST Chemistry Reference	1-Butanone, 4-chloro-1-(4-fluorophenyl)-(3874-54-2)
EPA Substance Registry System	1-Butanone, 4-chloro-1-(4-fluorophenyl)- (3874-54-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312a-P330-P501a

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38-20/21/22

Safety Statements

24/25-36-26

WGK Germany

Hazard Note

Irritant

TSCA

Yes

HS Code

2914790090

NFPA 704

	1
2		0

4-Chloro-4'-fluorobutyrophenone price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C43609	4-Chloro-4′-fluorobutyrophenone 97%	3874-54-2	25G	₹3810.4	2022-06-14	Buy
Sigma-Aldrich(India)	C43609	4-Chloro-4′-fluorobutyrophenone 97%	3874-54-2	100G	₹9753.33	2022-06-14	Buy
TCI Chemicals (India)	C1294	4-Chloro-4'-fluorobutyrophenone min. 97.0 %	3874-54-2	25G	₹2000	2022-05-26	Buy

Product number	Packaging	Price	Buy
C43609	25G	₹3810.4	Buy
C43609	100G	₹9753.33	Buy
C1294	25G	₹2000	Buy

4-Chloro-4'-fluorobutyrophenone Chemical Properties,Uses,Production

Chemical Properties

slightly yellow-greenish clear oil

Uses

4-Chloro-4''-fluorobutyrophenone (cas# 3874-54-2) is a compound useful in organic synthesis.

Uses

4-Chloro-4‘-fluorobutyrophenone is a pharmaceutical intermediate compound suitable for the production of antipsychotics and active pharmaceutical ingredients (APIs) for the treatment of depression.4-Chloro-4’-fluorobutyrophenone can be used as a synthesis of trifluprednis, azaperone, melperone, Melperone, Timiperone, Bromoperidol, Haloperidol, Benzoperidol, Droperidol, Fluanisone and other APIs as pharmaceutical intermediates.

Synthesis

The purified alkyne (5 mmol) was treated with a solution of HNTf2 (60-200 mol %) in 1,4-dioxane in apreheated oil bath at 100°C, under magnetic stirring, for 18-52 h, and the corresponding ketone was purified by column chromatography after cooling 4-Chloro-4'-fluorobutyrophenone. The reaction crude was purified by column chromatography using 20% AcOEt in n-hexane as an eluent. Isolated yield: 850 mg (85%). R f (20% AcOEt in n-hexane): 0.66. GC-MS (m/ z, M+? 200), major peaks found: 200 (1%), 164 (1%), 138 (43%), 123 (100%), 107 (10%). 1H NMR (δ, ppm; J, Hz): 8.03-7.97 (2C-H arom, mult), 7.17-7.09 (2C-H arom, mult), 3.68 (CH2, t, J = 6.2), 3.15 (CH2, t, J = 7.0), 2.22 (CH2, tt, J = 7.0, 6.2). 13C NMR (δ, ppm; J, Hz): 197.3 (C=O), 166.1 (C, d, J 1 C-F = 254.7), 133.2 (C, d, J 4 C-F = 4.3), 130.6 (2CH, d, J 3 C-F = 9.3), 115.9 (2CH, d, J 2 C-F = 22.2), 44.6 (CH2), 35.2 (CH2), 26.7 (CH2).
4-Chloro-4'-fluorobutyrophenone synthesis

4-Chloro-4'-fluorobutyrophenone Preparation Products And Raw materials

Raw materials

Preparation Products

ITI-722 Cyclopropyl 4-fluorophenyl ketone Ciproxifan

4-Chloro-4'-fluorobutyrophenone Suppliers

Global( 405)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
BTC pharm India	+918790379245	AndhraPradesh, India	1269	58	Inquiry
Firmus Laboratories Pvt Ltd	+918008045456	Hyderabad, India	41	58	Inquiry
3A Chemie Private Limited	+91-91-712-2564285 +91-9766589212	Maharashtra, India	57	58	Inquiry
VASUDHA PHARMA CHEM LIMITED	+91-91-4044763666 +91-9396659284	Telangana, India	102	58	Inquiry
A.R. LIFE SCIENCES PVT. LTD.	+91-914040267679 +91-8519993257	Hyderabad, India	100	58	Inquiry
GSV speciality chemicals	+91-91823634932 +91-91823634932	Hyderabad, India	135	58	Inquiry
Sadasivarao g	+91 9515157878	Hyderabad, India	107	58	Inquiry
MOLECRAFT LIFE SCIENCES PVT LTD	+91 9581188881	Telangana, India	189	58	Inquiry
SYNARTIS PHARMA PVT LTD	+919949688280	Hyderabad, India	92	58	Inquiry
V AND V PHARMA INDUSTRIES	+91 9773615371	Maharashtra, India	57	58	Inquiry

Supplier	Advantage
BTC pharm India	58
Firmus Laboratories Pvt Ltd	58
3A Chemie Private Limited	58
VASUDHA PHARMA CHEM LIMITED	58
A.R. LIFE SCIENCES PVT. LTD.	58
GSV speciality chemicals	58
Sadasivarao g	58
MOLECRAFT LIFE SCIENCES PVT LTD	58
SYNARTIS PHARMA PVT LTD	58
V AND V PHARMA INDUSTRIES	58

4-Chloro-4'-fluorobutyrophenone Spectrum

4-Chloro-4'-fluorobutyrophenone(3874-54-2)MS 4-Chloro-4'-fluorobutyrophenone(3874-54-2)¹HNMR 4-Chloro-4'-fluorobutyrophenone(3874-54-2)¹³CNMR 4-Chloro-4'-fluorobutyrophenone(3874-54-2)IR1 4-Chloro-4'-fluorobutyrophenone(3874-54-2)Raman

3874-54-2(4-Chloro-4'-fluorobutyrophenone)Related Search:

4-Fluorobenzaldehyde 2-Butanone oxime Epichlorohydrin 4-Methyl-2-pentanone Transfluthrin

Florfenicol N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium HALOPERIDOL RELATED COMPOUND A (15 MG) (4,4'-BIS[(4-P-CHLOROPHENYL)-4-HYDROXY-PIPERIDINO]-BU-TYROPHENONE) 3-CHLORO-4'-FLUOROPROPIOPHENONE 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(3-ethyl-4-fluorophenyl)-1-butanone

Haloperidol EP Impurity E GUTXTARXLVFHDK-GIVHGBEGSA-N 4-[4-(4-chloro-2,3,5,6-tetradeuteriophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one Dechloro Haloperidol (Haloperidol Impurity B) Cyclopropyl 4-fluorophenyl ketone

Haloperidol EP Impurity F 4-CHLORO-1-(2-FLUOROPHENYL)-1-OXOBUTANE 1-(4-FLUOROPHENYL)-4-HYDROXYBUTAN-1-ONE

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3-CHLOROPROPYL4-FLUOROPHENYLKETONE/4-CHLORO-4''-FLUOROBUTYROPHENONE 1-Butanone, 4-chloro-1-(4-fluorophenyl)- 1-(4-Fluorophenyl)-4-chloro-1-butanone γ-Chloro-4'-fluorobutyrophenone ω-Chloro-4'-fluorobutyrophenone Chloro-4'-fluorobutyrophe 4-Chloro-4'-fluorobu 4-chloro-4-fluorophenyl ketone 1-Chloro-4-(4-fluorophenyl)-4-oxobutane 3-(4-Fluorophenylcarbonyl)-1-chloropropane NSC 87082 4-Chloro-4'-fluoro-butyrophenone (OR) 3-(4-Fluorobenzoyl)propyl chloride 3-(p-Fluorobenzoyl)propyl chloride GAMMA-CHLORO-4-FLUOROBUTYROPHENONE GAMMA-CHLORO-P-FLUOROBUTYROPHENONE G-CHLORO-P-FLUOROBUTYROPHENONE AKOS BBS-00006481 4-CHLORO-1-(4-FLUOROPHENYL)-1-BUTANONE 4-CHLORO-1-(4-FLUOROPHENYL)-1-OXOBUTANE 4-CHLORO-4'-FLUOROBUTYROPHENONE 3-CHLOROPROPYL 4-FLUOROPHENYL KETONE TIMTEC-BB SBB003536 3-Chloro-4'-fluorobutyrophenone 4-(4-Fluorophenyl)-4-oxobutyl chloride 4-(p-Fluorophenyl)-4-oxobutyl chloride 4-chloro-1-(4-fluorophenyl)-1-butanon 4-Chloro-p-fluorobutyrophenone 4-Fluorobenzoylpropyl chloride Butyrophenone, 4-chloro-4'-fluoro- omega-Chloro-4-fluorobutyrophenone omega-Chloro-p-fluorobutyrophenone p-Fluoro-4-chlorobutyrophenone p-Fluorobenzoylpropyl chloride p-Fluoro-gamma-chlorobutyrophenone p-Fluoro-omega-chlorobutyrophenone Chloropfluorobutyrophenone OMEGA-CHLORO-4-FLUOROBUTYROPHENONE 97& 4-Chloro-4'-fluorobutyrophenone 97% 4-Chloro-4'-fluorobutyrophenone97% 4-CHLORO-4"-FLUOROBURYROPHENONE LUMAT-009 4-Cloro-4'-fluorobutirrofenone 4-CHLORO-4'-FLUOROBUTYROPHENONE BATCH NO: CFKT-10923/0319/FP/001 4-Chloro-4’-fluoro-butyrophenone (OR) 3-Chloropropyl-4-fluorophenyl ketone JACS-3874-54-2 4-Chloro-4'-fluorobutyrophenone > uorobutyrophenone Haloperidol Impurity 1 Haloperidol Decanoate Impurity 17 99% Purity 4-Chloro-4'-fluorobutyrophenone High Quality 4-Chloro-4'-fluorobutyrophenone 4-chloro-4 '-flubutanone 4-Chloro-4'Fluorobutyrophenone (FBP) 4-Chloro-4'-fluoroacetophenone 4-CHLORO-4-FLUOROBUTYROPHENONE Azaperone,Droperidol, Haloperidole,Timiperone 4-Chloro-4'-fluorobutyrophenone