Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cell Cycle >Chk inhibitor >CHIR-124

CHIR-124

CHIR-124 Structure
CAS No.
405168-58-3
Chemical Name:
CHIR-124
Synonyms
CS-2141;CHIR-124;CHIR-124 USP/EP/BP;CHIR-124 (CHIR124;4-[((3S)-1-Azabicyclo[2.2.2]oct-3-yl)amino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one;2(1H)-Quinolinone, 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylaMino]-3-(1H-benziMidazol-2-yl)-6-chloro-;(S)-3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one , CHIR-124;Platelet-derived growth factor receptor,PDGFR,CHIR-124,Checkpoint Kinase (Chk),CD135,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,inhibit,Apoptosis,Inhibitor,FLT3
CBNumber:
CB32561465
Molecular Formula:
C23H22ClN5O
Molecular Weight:
419.91
MOL File:
405168-58-3.mol
Modify Date:
2024/7/2 8:55:06
Request For Quotation

CHIR-124 Properties

Density 1.46
storage temp. Store at -20°C
solubility insoluble in H2O; ≥10.5 mg/mL in DMSO; ≥2.61 mg/mL in EtOH with gentle warming
form solid
pka 9.00±0.70(Predicted)
color Light yellow to brown

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

CHIR-124 Chemical Properties,Uses,Production

Description

Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. CHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC50 = 0.3 nM in vitro). It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher against Chk2 (IC50 = 0.7 μM). In synergy with topoisomerase I poisons or ionizing radiation, CHIR124 can inhibit the growth of p53-mutant solid tumor cells both in vitro and in a xenograft model, potentiating tumor apoptosis.

Uses

CHIR 124 is a cell-permeable molecule with a quinolone-based structure. It inhibits checkpoint kinase 1 (Chk1) which regulates S and G2-M cekk cycle checkpoints in response to DNA damage. Application towards inhibition of tumor cell growth.

CHIR-124 Preparation Products And Raw materials

Raw materials

Preparation Products

CHIR-124 Suppliers

Global( 83)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24200 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
InvivoChem 13549236410 China 6755 58 Inquiry
Hubei Kele Fine Chemical Co., Ltd 027-59101668 19945030958 China 7969 58 Inquiry
Supplier Advantage
career henan chemical co 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
InvivoChem 58
Hubei Kele Fine Chemical Co., Ltd 58

CHIR-124 Spectrum

CHIR-124(405168-58-3)1HNMR

405168-58-3(CHIR-124)Related Search:

8-AZAGUANINE LY2603618 Selumetinib MK-8776 (SCH 900776) AZD7762
CHIR-99021 Olaparib
chevron_left

1of2

chevron_right
CHIR-124 2(1H)-Quinolinone, 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylaMino]-3-(1H-benziMidazol-2-yl)-6-chloro- 4-[((3S)-1-Azabicyclo[2.2.2]oct-3-yl)amino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one CS-2141 CHIR-124 (CHIR124 CHIR-124 USP/EP/BP Platelet-derived growth factor receptor,PDGFR,CHIR-124,Checkpoint Kinase (Chk),CD135,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,inhibit,Apoptosis,Inhibitor,FLT3 (S)-3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one , CHIR-124 405168-58-3 Inhibitors