(6R,trans)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

(6R,trans)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Structure
CAS No.
171489-03-5
Chemical Name:
(6R,trans)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Synonyms
Tadalafil Catechol;Tadalafil IMpurity K;Tadalafil Impurity 43;Tadalafil Impurity 48;DesMethylene Tadalafil;Tadalafil IMpurity: IMpurity I;Tadalafil Desmethylene Impurity;(6R,12aR)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;(6R,trans)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;(6R,12aR)-6-(3,4-Dihydroxyphenyl)-2-methyl-2,3,6,7,12,12a-hexahydro pyrazino [1′,2′:1,6]-pyrido[3,4-b]indole-1,4-dione
CBNumber:
CB32620915
Molecular Formula:
C21H19N3O4
Molecular Weight:
377.39
MOL File:
171489-03-5.mol
Modify Date:
2024/4/25 17:59:01

(6R,trans)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Properties

Melting point >215°C (dec.)
Boiling point 735.3±60.0 °C(Predicted)
Density 1.56±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Sparingly), Methanol (Slightly)
pka 9.58±0.10(Predicted)
form Solid
color Off-White to Light Pink
Stability Hygroscopic

(6R,trans)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Chemical Properties,Uses,Production

Chemical Properties

Off-White to Pale Pink Solid

Uses

Tadalafil. A phosphodiesterase 5 inhibitor.

(6R,trans)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Preparation Products And Raw materials

Raw materials

Preparation Products

(6R,12aR)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione (6R,trans)-6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione DesMethylene Tadalafil Tadalafil IMpurity: IMpurity I Tadalafil IMpurity K Tadalafil Desmethylene Impurity Tadalafil Catechol Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(3,4-dihydroxyphenyl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)- Tadalafil Impurity 48 Tadalafil Impurity 43 (6R,12aR)-6-(3,4-Dihydroxyphenyl)-2-methyl-2,3,6,7,12,12a-hexahydro pyrazino [1′,2′:1,6]-pyrido[3,4-b]indole-1,4-dione 171489-03-5 Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals