ChemicalBook > Product Catalog >Organic Chemistry >Phosphines >(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

CAS No.: 1197953-49-3

Chemical Name:: (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Synonyms: (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide;AP26113 intermediates 1;4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine;2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine;2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine;2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami...;4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]-;2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide;2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine *

CBNumber:: CB32677388

Molecular Formula:: C12H12Cl2N3OP

Molecular Weight:: 316.12

MOL File:: 1197953-49-3.mol

MSDS File:: SDS

Modify Date:: 2024/4/9 22:15:29

Request For Quotation

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Properties

Boiling point	527.5±50.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	0.30±0.10(Predicted)
InChI	InChI=1S/C12H12Cl2N3OP/c1-19(2,18)10-6-4-3-5-9(10)16-11-8(13)7-15-12(14)17-11/h3-7H,1-2H3,(H,15,16,17)
InChIKey	XIKUAKVCJMVXCI-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Chemical Properties,Uses,Production

Uses

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide is an intermediate of AP26113 which is a kind of effective ALK inhibitor.

Synthesis

25 mL of a one-necked flask was added DMF (3 mL), 2,5,6-trichloro pyrimidine (0.72 g, 3.9 mmol) was added successively with stirring,2- (dimethylphosphonino) aniline (0.5 g, 3 mmol)Anhydrous potassium carbonate (0.62 g, 4.5 mmol), heated to 60 ° C and stirred for 4 h.(30 mL x 2), the organic phase was combined, washed with water (60 mL x 2), and the organic layer was dried over anhydrous sodium sulfate, and the organic layer was washed with ethyl acetate (30 mL) and water (30 mL) Filtered and concentrated, and the residue was passed through a silica gel column to give 0.8 g of a pale yellow solid (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Preparation Products And Raw materials

Raw materials

2-(diMethylphosphoryl)aniline 2,4,5-Trichloropyrimidine

Preparation Products

(2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Suppliers

Global( 162)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Bulat Pharmaceutical Pvt Ltd	+91-8448085659 +91-8448085660	Haryana, India	123	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Enki Biopharmaceuticals (Shanghai) Limited	+86-0086-2157680326 +8613916707528	China	46	58	Inquiry
Shanghai Famo Biotech Co Ltd	+8618550473860	China	513	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20296	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16925	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry

Supplier	Advantage
Bulat Pharmaceutical Pvt Ltd	58
A.J Chemicals	58
Enki Biopharmaceuticals (Shanghai) Limited	58
Shanghai Famo Biotech Co Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Fuxin Pharmaceutical	58

1197953-49-3((2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide)Related Search:

1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- 4-fluoro-2-Methoxy-5-nitroaniline 1-(1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl)-4-Methylpiperazine 2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline 2-(diMethylphosphoryl)aniline

2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine 4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine 2-[(2,5-Dichloro-4-pyrimidinyl)amino]phenyl]dimethylphosphine Oxide 2,5-Dichloro-N-[2-(dimethylphosphinyl)phenyl]-4-pyrimidinamine 4-Pyrimidinamine, 2,5-dichloro-N-[2-(dimethylphosphinyl)phenyl]- 2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-ami... (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide 2,5- Dichloro -N-[2- (dimethylphosphino) phenyl ]-4- pyrimidinamine * AP26113 intermediates 1 1197953-49-3 197953-49-3 761140-75-9 C12H12Cl2N3OP 1197953-49-3