SHR1258

SHR1258 Structure
CAS No.
1269662-73-8
Chemical Name:
SHR1258
Synonyms
SHR1258;HTI-1001;SHR-1258;Pyrotinib;SHR-1258;SHR1258;Pyrotinib (SHR-1258);Pyrotinib (free base);(R,E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide;2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-, (2E)-
CBNumber:
CB33159982
Molecular Formula:
C32H31ClN6O3
Molecular Weight:
583.08
MOL File:
1269662-73-8.mol
Modify Date:
2024/7/2 8:55:06

SHR1258 Properties

Boiling point 775.5±60.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 0.172 mg/mL (0.29 mM)
pka 12.30±0.43(Predicted)
form Solid
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280

SHR1258 Chemical Properties,Uses,Production

Uses

Pyrotinib, is a potent and selective EGFR/HER2 dual inhibitor.

SHR1258 SHR-1258 SHR-1258;SHR1258 Pyrotinib (SHR-1258) Pyrotinib 2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-, (2E)- Pyrotinib (free base) HTI-1001 (R,E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide 1269662-73-8