CIS-THIOTHIXENE
- CAS No.
- 5591-45-7
- Chemical Name:
- CIS-THIOTHIXENE
- Synonyms
- Navan;Navane;Navaron;p-4657-b;Orbinamon;Tiotixene;cp12252-1;CP 12252-1;Thiothixine;Cp-12,252-1
- CBNumber:
- CB3504781
- Molecular Formula:
- C23H29N3O2S2
- Molecular Weight:
- 443.63
- MOL File:
- 5591-45-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:53
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H351 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501 | |||||||||
| NFPA 704 |
|
CIS-THIOTHIXENE Chemical Properties,Uses,Production
Description
In 2002, the American Association of Poison Control Centers’ Toxic Exposure Surveillance System reported 5224 human exposures to phenothiazines, thioxanthenes, and other neuroleptic medications; 3691 were in adults and 808 in children. Unintentional and intentional exposures accounted for 43.7 and 47.8%, respectively. There were 417 (8.0%) adverse drug reactions reported. Thioxanthenes are chemical compounds in which the oxygen atom in xanthene is replaced with a sulfur atom. They are also related to phenothiazines. Several derivatives are used as typical antipsychotics in the treatment of schizophrenia and other psychoses. The thioxanthenes, as a class, are closely related chemically to the phenothiazines. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain, as shown in the chemical structure of flupenthixol, which has a double-bonded carbon in the number 10 position. Clopenthixol is a typical antipsychotic drug of the thioxanthenes class and a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.
Uses
Thioxanthenes are used as neuroleptic agents, antipsychotics,
and major tranquilizers in the treatment of psychosis,
including schizophrenia, senile psychosis, pathological jealousy,
and borderline personality disorder. Other uses include
the treatment of pain, postoperative neuralgia, sedation,
anxiety neurosis, childhood behavior problems, and depression.
The maximum therapeutic daily oral dose for chlorprothixene,
flupenthixol, and thiothixene is 600, 224, and 60 mg, respectively; the maximum intramuscular doses are
200 mg day-1, 100 mg weekly, and 30 mg day-1, respectively.
Some thioxanthenes and thioxanthenones have shown signs of
possible human therapeutic potential against tumors in mice
and in vitro assays, and some thioxanthenes have been shown
to have cytotoxic and antimicrobial activities.
Chlorprothixene is primarily indicated in conditions such as
agitation, mania, psychosis, schizophrenia, and can also be given
in adjunctive therapy as an alternative drug of choice for anxiety
and herpetic neuralgia. Flupenthixol (HCl and decanoate) is
primarily indicated in conditions such as depression, muscle
spasms of varied etiology, pain, personality disorder, postoperative
nausea and vomiting, psychosis, relief of discomfort in
mild urinary tract infections, and schizophrenia. Flupenthixol is
also seen to possess powerful antibacterial activity both in vitro
and in vivo in mouse experiments. It is bacteriostatic in vitro both
against gram-positive and gram-negative bacteria. Thiothixene is
used in the management of schizophrenia. It has not been
evaluated in the management of behavioral complications in
patients with mental retardation.
Zuclopenthixol is primarily indicated in conditions such
as dementia, to enhance permeation of subcutaneous or intramuscular injections, labyrinthine disorders, prolactinoma,
psychosis, schizophrenia, and second trimester abortion. It is
also used in the treatment of acute bipolar mania.
Environmental Fate
Long-range transport: handling of thioxanthenes should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. In case of handling, avoid inhalation and contact with skin, eyes, and clothing, as these materials may be an irritant. These substances are considered nonhazardous for transport.
CIS-THIOTHIXENE Preparation Products And Raw materials
Raw materials
Preparation Products
CIS-THIOTHIXENE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Angle Biopharma | 08046067501 | Ahmedabad, India | 142 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| NOVITIUM PHARMA LLC | 855.204.1431 | United States | 13 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9708 | 58 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry |