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ChemicalBook > Product Catalog >Analytical Chemistry >Standard >(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one

(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one

(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Structure
CAS No.
139893-81-5
Chemical Name:
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
Synonyms
(1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one;Edoxaban Impurity 80;6-Oxabicyclo[3.2.1]octan-7-one, 4-bromo-, (1S-exo)- (9CI);(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-oneQ: What is (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Q: What is the CAS Number of (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
CBNumber:
CB35925598
Molecular Formula:
C7H9BrO2
Molecular Weight:
205.05
MOL File:
139893-81-5.mol
Modify Date:
2023/12/13 13:10:17
Request For Quotation

(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Properties

Boiling point 324.2±25.0 °C(Predicted)
Density 1.642±0.06 g/cm3(Predicted)
InChI InChI=1/C7H9BrO2/c8-5-2-1-4-3-6(5)10-7(4)9/h4-6H,1-3H2/t4-,5?,6?/s3
InChIKey HIEDNXSBEYNHJB-OGAAFCRYNA-N
SMILES [C@]12([H])CC(OC1=O)C(Br)CC2 |&1:0,r|

(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Chemical Properties,Uses,Production

Uses

Used as Edoxaban impurity.

Synthesis

(1S)-Cyclohex-3-ene-1-carboxylic acid (II) (5 g) was dissolved in dichloromethane (25 mL). To this solution, N-bromosuccinimide (1.1 mole) was added at room temperature. In two lots, calcium oxide (0.25 mole) was charged to the Suspension. The reaction mixture was stirred at 20 to 25°C for 1 hour and filtered. The bed was washed with dichloromethane (10 mL). The washings were combined with the filtrate, and the solvent was recovered under vacuum at 35 to 40 °C. Deionized water (50 mL) was charged to the solid, heated to 50 °C, stirred for 10 minutes, and filtered. The bed was washed with deionized water (10 mL) and suction dried. The solid was dried under vacuum at 45-50 °C to get (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one. Yield: 61%

(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Preparation Products And Raw materials

Raw materials

Preparation Products

tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Edoxaban Impurity 16 3-Cyclohexene-1-carboxylic acid, (1S)-, compd. with (αR)-α-methylbenzenemethanamine (1:1)

(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Suppliers

Global( 27)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Changzhou Guiding Bio-Tech. Co.,Ltd. +86-519-519-86686860 +8618795626222 China 299 58 Inquiry
Eaglech（shanghai）Pharmaceutical Co., Ltd +8613884467586 China 8 58 Inquiry
China National Standard Pharmaceutical Corporation Limited +8615391658522 China 11927 58 Inquiry
Wuhan Fortuna Chemical Co.,Ltd +8618007136271 China 5774 58 Inquiry
Watson Biotechnology Co.,Ltd +86-18186686046 +86-18186686046 China 5814 58 Inquiry
Shaanxi Dideu Newmaterial Co., Ltd. 029-63373950 15353716720 China 10011 58 Inquiry
FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd 025-86979920 18118984557 China 183 58 Inquiry
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 18013972705 China 6763 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
Changzhou Guiding Bio-Tech. Co.,Ltd. 58
Eaglech（shanghai）Pharmaceutical Co., Ltd 58
China National Standard Pharmaceutical Corporation Limited 58
Wuhan Fortuna Chemical Co.,Ltd 58
Watson Biotechnology Co.,Ltd 58
Shaanxi Dideu Newmaterial Co., Ltd. 58
FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58
6-Oxabicyclo[3.2.1]octan-7-one, 4-bromo-, (1S-exo)- (9CI) Edoxaban Impurity 80 (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-oneQ: What is (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Q: What is the CAS Number of (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one 139893-81-5