ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Pyridine derivatives >6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- CAS No.
- 6636-55-1
- Chemical Name:
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- Synonyms
- AKOS BBS-00004651;Sorafenib Impurity 117;methyl 6-chloropicolinate;6-Chloropicolinic acid methyl ester;methyl (6-chloropyridin-2-yl)acetate;methyl 6-chloro-2-pyridinecarboxylate;METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE;2-chloropyridine-6-carboxylate methyl;methyl 2-(6-chloropyridin-2-yl)acetate;6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- CBNumber:
- CB3780710
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MOL File:
- 6636-55-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/9 22:15:29
| Melting point | 93-94° |
|---|---|
| Boiling point | 275.8±20.0 °C(Predicted) |
| Density | 1.294±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -1.03±0.10(Predicted) |
| form | Solid |
| color | Pale yellow |
| Water Solubility | Slightly soluble in water. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
6-CHLORO-2-PICOLINIC ACID METHYL ESTER price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | M2640 | Methyl 6-Chloro-2-pyridinecarboxylate min. 98.0 % | 6636-55-1 | 1G | ₹2000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M2640 | Methyl 6-Chloro-2-pyridinecarboxylate min. 98.0 % | 6636-55-1 | 5G | ₹2400 | 2022-05-26 | Buy |
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Chemical Properties,Uses,Production
Uses
Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.
Synthesis Reference(s)
Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867
Synthesis
6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 214)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Terma Medicare India Pvt.,Ltd | +8613916485955 | Rajasthan, India | 145 | 58 | Inquiry |
| ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED | +919966658228 | Hyderabad, India | 486 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20296 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
6636-55-1(6-CHLORO-2-PICOLINIC ACID METHYL ESTER)Related Search:
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Methyl 6-Chloropyridine-2-carboxylate, 97+%
METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE
AKOS BBS-00004651
6-CHLOROPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6-Chloro-2-pyridinecarboxylic acid methyl ester
6-Chloropicolinic acid methyl ester
2-Pyridinecarboxylic acid, 6-chloro-, methyl ester
methyl 6-chloro-2-pyridinecarboxylate
methyl 2-(6-chloropyridin-2-yl)acetate
methyl 6-chloropicolinate
methyl (6-chloropyridin-2-yl)acetate
2-chloropyridine-6-carboxylate methyl
6-chloro-2-picolonic acid methyl ester
Methyl 6-chloropicolinate, 2-Chloro-6-(methoxycarbonyl)pyridine
6-Chloro-2-picolinic acid methyl ester Solution
Methyl 6-Chloro-2-pyridinecarboxylate >
Methyl6-chloropyridine-2-carboxylate,95%
6-CHLORO-2-PICOLINIC ACID METHYL ESTER ISO 9001：2015 REACH
Sorafenib Impurity 117
6636-55-1
Picolinic acid series