Diquafosol Tetrasodium
- CAS No.
- 211427-08-6
- Chemical Name:
- Diquafosol Tetrasodium
- Synonyms
- D03864;INS 365;CID 9876095;Diquafosol sodium;Diquafosoftetrasodium;Diquafosol tetrasodium;Diquafosol sodium (jan);Dexamethoxol tetrasodium;Diquafosol Tetrasodium CRS;Diquafosol Tetrasodium Salt
- CBNumber:
- CB41347117
- Molecular Formula:
- C18H27N4NaO23P4
- Molecular Weight:
- 814.3
- MOL File:
- 211427-08-6.mol
- Modify Date:
- 2025/2/12 13:10:04
| storage temp. | Store at -20°C |
|---|---|
| solubility |
DMSO:1.0(Max Conc. mg/mL);1.14(Max Conc. mM) Water:100.0(Max Conc. mg/mL);113.86(Max Conc. mM) |
| form | A solid |
| color | White to off-white |
| optical activity | [α]/D -12.0 to -8.0°, c =1.0 in H2O |
| Water Solubility | H2O: 2mg/mL, clear |
| InChIKey | XPZQVLUPTGTIJP-NIBQMMLDNA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H228 | |||||||||
| Precautionary statements | P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| NFPA 704 |
|
Diquafosol Tetrasodium Chemical Properties,Uses,Production
Description
Diquafosol (INS-365) was approved in Japan in 2010 as a 3% ophthalmic solution for treatment of dry eye disease. Clinical diagnosis of dry eye is difficult because the condition presents a variety of symptoms. Treatment options include tear supplements (lubricants), anti-inflammatory drugs (e.g., cyclosporine eye drops or steroid eye drops), and tear retention devices. Diquafosol is a unique agent for the treatment of dry eye in that it acts as a P2Y2 purinergic receptor agonist with the ability to activate this receptor on the ocular surface and stimulate water, lipid, and mucin secretion. Diquafosol is metabolized by phosphodiesterases to UTP, UDP, UMP, and uridine. Diquafosol has been well tolerated in clinical trials, with side effects being local to the ocular surface.In addition,no serious ocular or systemic adverse drug reactions were found during the clinical trials.
Uses
Enhancement of mucosal hydration in the treatment of chronic dry eye (P2Y2 receptor antagonist).
Clinical Use
Diquafosol tetrasodium was approved in April 2010 as Diquas ® ophthalmic solution 3% for the treatment of dry eye syndrome and launched in Japan by Santen Pharmaceuticals. Diquafosol tetrasodium was originally discovered by Inspire Pharmaceuticals. In 2001, it was licensed to Santen for co-development and commercialization in Asian countries, and co-developed in collaboration with Allergan for the countries outside of Asia. In the U.S., diquafosol tetrasodium was submitted for a New Drug Application (NDA) as Prolacria ®(2% ophthalmic formulation) in June 2003. However, it is still in Phase III clinical development for dry eye syndrome. Diquafosol tetrasodium, also known as INS- 365, is a P2Y2 receptor agonist, which activates P2Y2 receptor on the ocular surface, leading to rehydration through activation of the fluid pump mechanism of the accessory lacrimal glands on the conjunctival surface.
Diquafosol Tetrasodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Guangzhou Tosun Pharmaceutical Limited | +8618922120635 | China | 998 | 58 | Inquiry |
| Guangzhou Tosun Pharmaceutical Ltd | +86-020-61855200-902 +8618124244216 | China | 897 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21628 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29808 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10244 | 58 | Inquiry |
Related articles
- Diquafosol tetrasodium: synthesis, uses and Mode of action
- Diquafosol tetrasodium, a uridine 5′-triphosphate (UTP) analogue, is an agonist of the purinergic P2Y2 receptor.
- Jan 17，2025
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