L-Threonine Benzyl Ester Hydrochloride
- CAS No.
- 33645-24-8
- Chemical Name:
- L-Threonine Benzyl Ester Hydrochloride
- Synonyms
- L-THR;L-THR;L-Thr-OBzl HCl;L-THREONINE BENZYL ESTER HCL;Benzyl L-threoninate hydrochloride;L-THREONINE BENZYL ESTER HYDROCHLORIDE;L-THREONINE BENZYL ESTER HYDROCHLORIDE USP/EP/BP;L-Threonine, phenylmethyl ester, hydrochloride (1:1);L-Threonine Benzyl Ester Hydrochloride;benzyl (2S,3R)-2-amino-3-hydroxybutanoate hydrochloride
- CBNumber:
- CB41505896
- Molecular Formula:
- C11H16ClNO3
- Molecular Weight:
- 245.70264
- MOL File:
- 33645-24-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/3 12:01:51
| Melting point | 128.0 to 132.0 °C |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| color | White to Almost white |
| InChI | InChI=1/C11H15NO3.ClH/c1-8(13)10(12)11(14)15-7-9-5-3-2-4-6-9;/h2-6,8,10,13H,7,12H2,1H3;1H/t8-,10+;/s3 |
| InChIKey | IDZGTFSDZJVMSD-YFYURQRANA-N |
| SMILES | C(OCC1=CC=CC=C1)(=O)[C@H]([C@H](O)C)N.[H]Cl |&1:10,11,r| |
| CAS DataBase Reference | 33645-24-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2922500090 |
L-Threonine Benzyl Ester Hydrochloride price More Price(2)
L-Threonine Benzyl Ester Hydrochloride Chemical Properties,Uses,Production
References
[1] Charles M, et al. Serine and Threonine Schiff Base Esters React with β-Anomeric Peracetates in the Presence of BF3·Et2O to Produce β-Glycosides. Journal of Carbohydrate Chemistry, 2010; 29.
Uses
L-threonine benzyl ester hydrochloride salt was reacted with the diaryl ketimine bis-(4-methoxyphenyl)-methenamine in CH3CN at rt to form the more nucleophilic L-threonine Schiff base (Benzyl N-bis (4-methoxyphenyl)methylene-L-threoninate) in excellent yield. In addition, L-threonine Schiff base, acting as glycosyl acceptor, reacted at rt with simple sugar peracetate donor with BF3·OEt2 promotion to provide the corresponding L-threonine O-linked glycosides in excellent yields and purities[1].
Preparation
The benzyl ester hydrochloride salt, L-Threonine Benzyl Ester Hydrochloride, was prepared from L-threonine and PhCH2OH in the presence of p-toluenesulfonic acid[1]. Specifically, L-Threonine (4.0 g, 34 mmol) and pTsOH acid monohydrate (7.10 g, 38 mmol) were reacted with benzyl alcohol (40 mL) in 50 mL dry benzene using a Dean-Stark apparatus according to the procedure of Petursson and Bald-win. Yield:71.3%
L-Threonine Benzyl Ester Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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