ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >mTOR inhibitors >KU-0063794

KU-0063794

CAS No.: 938440-64-3

Chemical Name:: KU-0063794

Synonyms: CS-28;KU0063794;KU 0063794, >=98%;KU0063794(KU63794);KU-0063794 USP/EP/BP;Pholcodine Impurity 8;KU-0063794(KU 0063794);mTOR Inhibitor IV, Ku-63794;KU-0063794;KU 0063794; KU0063794;mTOR Inhibitor IV Ku-63794 Ku63794

CBNumber:: CB42468008

Molecular Formula:: C25H31N5O4

Molecular Weight:: 465.54

MOL File:: 938440-64-3.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

KU-0063794 Properties

Boiling point	694.3±65.0 °C(Predicted)
Density	1.248
storage temp.	2-8°C
solubility	DMSO: >2mg/mL (warmed)
form	powder
pka	14.20±0.10(Predicted)
color	white to beige
InChIKey	RFSMUFRPPYDYRD-CALCHBBNSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P264-P270-P301+P310-P321-P330-P405-P501

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

NFPA 704

	0
2		0

KU-0063794 price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0382	KU 0063794 ≥98% (HPLC)	938440-64-3	5MG	₹15544.7	2022-06-14	Buy
Sigma-Aldrich(India)	SML0382	KU 0063794 ≥98% (HPLC)	938440-64-3	25MG	₹62633.45	2022-06-14	Buy
Sigma-Aldrich(India)	475990	mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem The mTOR Inhibitor IV, Ku-63794, also referenced under CAS 938440-64-3, controls the biological activity of mTOR. This small molecule/inhibitor is pri	938440-64-3	5MG	₹17860	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0382	5MG	₹15544.7	Buy
SML0382	25MG	₹62633.45	Buy
475990	5MG	₹17860	Buy

KU-0063794 Chemical Properties,Uses,Production

Description

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival. Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC₅₀ = 10 nM). It does not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks. Ku-0063794 inhibits cell growth by inducing G₁-cell cycle arrest and autophagy, but not apoptosis, and inhibits tumor growth in a xenograft model of renal cell carcinoma (8 mg/kg for 46 days).

Uses

Ku 0063794 is a specific mammalian target of rapamycin (mTOR) inhibitor and may be used for the treatment of cancers.

Definition

ChEBI: A member of the class of pyridopyrimidines that is an mTOR inhibitor and shows anti-tumour properties.

Biological Activity

Selective inhibitor of mammalian target of rapamycin (mTOR) (IC 50 ~10 nM for mTORC1 and mTORC2 respectively). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G 1 cell cycle arrest in vitro .

KU-0063794 Preparation Products And Raw materials

Raw materials

Preparation Products

KU-0063794 Suppliers

Global( 141)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29892	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58

KU-0063794 Spectrum

KU-0063794(938440-64-3)¹HNMR

938440-64-3(KU-0063794)Related Search:

Everolimus AZD-8055 MK-2206 2HCl Torin 1 Erlotinib hydrochloride

Rapamycin

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BENZENEMETHANOL, 5-[2-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-4-(4-MORPHOLINYL)PYRIDO[2,3-D]PYRIMIDIN-7-YL]-2-METHOXY-, REL- KU0063794 5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol (5-(2-((2R,6S)-2,6-Dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol KU0063794(KU63794) KU-0063794(KU 0063794) BENZENEMETHANOL, 5-[2-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-4-(4-MORPHOLINYL)PYRIDO[2,3-D]PYRIMIDIN-7 5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol KU-0063794 KU-0063794,Etoposide,Etopl,Vepeside. KU 0063794, >=98% KU-0063794;KU 0063794; KU0063794 (5-(2-((2R,6S)-2,6-Dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxypheny mTOR Inhibitor IV, Ku-63794 CS-28 mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem KU-0063794 USP/EP/BP (5-(2-((2S,6R)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol [5-[2-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]-4-morpholino-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl]methanol (5-(2-(cis-2,6-Dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol mTOR Inhibitor IV Ku-63794 Ku63794 Pholcodine Impurity 8 938440-64-3 C25H31N5O4 Inhibitors Akt mTOR PI3K