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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >A66

A66

A66 Structure
CAS No.
1166227-08-2
Chemical Name:
A66
Synonyms
CS-435;A 66;A-66;A66 USP/EP/BP;A66 PI3K inhibitor A-66;A66, 98%, a potent and specific p110α inhibitor;Phosphoinositide 3-kinase,inhibit,PI3K,A66,Inhibitor,A-66,A 66;(2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide;(S)-N1-(2-(tert-Butyl)-4'-methyl-[4,5'-bithiazol]-2'-yl)pyrrolidine-1,2-dicarboxamide;(2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide;(2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
CBNumber:
CB42553771
Molecular Formula:
C17H23N5O2S2
Molecular Weight:
393.53
MOL File:
1166227-08-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:08
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A66 Properties

Density 1.354
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility insoluble in H2O; ≥19.7 mg/mL in DMSO; ≥2.63 mg/mL in EtOH with gentle warming
form solid
pka 6.27±0.70(Predicted)
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  29341000

A66 Chemical Properties,Uses,Production

Description

A-66 is a potent, selective inhibitor of the PI3K isoform p110α (IC50 = 32 nM in a cell-free assay). It displays over 100-fold selectivity for p110α over other isoforms. A-66 is effective in vivo, suppressing the growth of SK-OV-3 tumor xenografts in mice. It also impairs all measures of in vivo insulin action in mice. A-66 partially suppresses B cell receptor-dependent Akt activation and proliferation.

Enzyme inhibitor

This potent and highly selective p110α inhibitor (FW = 393.53; CAS 1166227-08-2; Solubility: 79 mg/mL DMSO, 1 mg/mL H2O), also known as (2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1, 2-dicarboxamide, has a IC50 value of 32 nM for the wild-type phosphoinositide-3 kinase p110 α as well as oncogenic forms of p110α such as p110α E545K (IC50 = 43 nM) and p110α H1047R (IC50 = 43 nM). A66 inhibition also demonstrated that cancer-specific mutations in the iSH2 (inter-SH2) and nSH2 (N-terminal SH2) domains of p85α, the regulatory subunit of phosphatidylinositide 3-kinase (PI3K), show gain of function, inducing oncogenic cellular transformation, stimulating cellular proliferation, and enhancing PI3K signaling.

A66 Preparation Products And Raw materials

Raw materials

Preparation Products

A66 Suppliers

Global( 116)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58

A66 Spectrum

A66(1166227-08-2)1HNMR

1166227-08-2(A66)Related Search:

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(2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide (2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide (2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide A 66 CS-435 A66, 98%, a potent and specific p110α inhibitor (2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide A 66;A-66 1,2-Pyrrolidinedicarboxamide, N1-[2-(1,1-dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-, (2S)- A66 USP/EP/BP A66 PI3K inhibitor A-66 Phosphoinositide 3-kinase,inhibit,PI3K,A66,Inhibitor,A-66,A 66 (S)-N1-(2-(tert-Butyl)-4'-methyl-[4,5'-bithiazol]-2'-yl)pyrrolidine-1,2-dicarboxamide 1166227-08-2 C17H23N5O2S2 Inhibitors Akt mTOR PI3K PI3K/Akt/mTOR