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SC 66

SC 66 Structure
CAS No.
871361-88-5
Chemical Name:
SC 66
Synonyms
SC 66;CS-2480;SC66;SC 66;2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
CBNumber:
CB42565930
Molecular Formula:
C18H16N2O
Molecular Weight:
276.33
MOL File:
871361-88-5.mol
Modify Date:
2023/6/30 15:45:59
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SC 66 Properties

storage temp. Sealed in dry,2-8°C
solubility DMSO: ≥5mg/mL (warmed)
form powder
color faint yellow to dark yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

SC 66 Chemical Properties,Uses,Production

Description

Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.

Uses

SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.

SC 66 Preparation Products And Raw materials

Raw materials

Preparation Products

SC 66 Suppliers

Global( 93)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29821 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
LEAPCHEM CO., LTD. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58

871361-88-5(SC 66)Related Search:

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester SC-514 SC 57461A α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
SC 66 Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)- (2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone CS-2480 SC66;SC 66 (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis 2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA 871361-88-5