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ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >(1R,2S)-2-fluorocyclopropanecarboxylic acid

(1R,2S)-2-fluorocyclopropanecarboxylic acid

(1R,2S)-2-fluorocyclopropanecarboxylic acid Structure
CAS No.
167073-08-7
Chemical Name:
(1R,2S)-2-fluorocyclopropanecarboxylic acid
Synonyms
(1R,2S)-2-fluorocyclopropane-1-carboxylic acid;Sitafloxacin Impurity 26;(1R,2S)-2-fluorocyclopropanecarboxylic acid;(1R,2S)-trans-2-Fluorocyclopropanecarboxylic acid 97%;Cyclopropanecarboxylic acid, 2-fluoro-, (1R-trans)- (9CI)
CBNumber:
CB42610540
Molecular Formula:
C4H5FO2
Molecular Weight:
104.08
MOL File:
167073-08-7.mol
Modify Date:
2024/1/4 9:26:36
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(1R,2S)-2-fluorocyclopropanecarboxylic acid Properties

Boiling point 202.3±33.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
pka 4.00±0.11(Predicted)
InChI InChI=1S/C4H5FO2/c5-3-1-2(3)4(6)7/h2-3H,1H2,(H,6,7)/t2-,3-/m0/s1
InChIKey HZQKMZGKYVDMCT-HRFVKAFMSA-N
SMILES [C@H]1(C(O)=O)C[C@@H]1F

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02
Signal word  Danger
Hazard statements  H225
Precautionary statements  P210-P273-P243-P403
HS Code  2916200090

(1R,2S)-2-fluorocyclopropanecarboxylic acid Chemical Properties,Uses,Production

Synthesis

Dissolve benzyl alcohol and allyl bromide in the solvent, add sodium hydride, and perform a condensation reaction to obtain allyl benzyl ether. The obtained allyl benzyl ether, dichlorofluoromethane, and sodium hydroxide solution are raw materials for carbene reaction to obtain 2-chloro-2-fluorocyclopropylmethyl benzyl ether. Subsequently, the obtained 2-chloro-2-fluorocyclopropylmethylbenzyl ether is hydrogenated and reduced to obtain 2-chloro-2-fluorocyclopropanemethanol. Sodium hypochlorite is added as an oxidizing agent to perform an oxidation reaction to obtain 2-chloro-2-fluorocyclopropanecarboxylic acid. Finally, diethylamine is added to perform a hydrogenation reduction reaction to obtain (1R,2S)-2-fluorocyclopropanecarboxylic acid. (1R,2S)-2-fluorocyclopropanecarboxylic acid

(1R,2S)-2-fluorocyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(1R,2S)-2-fluorocyclopropanecarboxylic acid Suppliers

Global( 64)Suppliers
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Suzhou Chukai Pharma Tech Co.,Ltd +86-15151706780; +8615062531973 China 402 58 Inquiry
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 China 29730 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-+86-371-66670886 China 19841 58 Inquiry
Accela ChemBio Inc. +1-858-6993322 United States 20014 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24727 58 Inquiry
Golden Pharma Co., Limited +undefined18958062155 China 5899 58 Inquiry
Henan Aochuang Chemical Co.,Ltd. +86-0371-63689365 +8618638391208 China 9297 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3135 58 Inquiry
Protheragen-ING +16313385890 United States 3868 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
Supplier Advantage
Suzhou Chukai Pharma Tech Co.,Ltd 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
Accela ChemBio Inc. 58
LEAP CHEM CO., LTD. 58
Golden Pharma Co., Limited 58
Henan Aochuang Chemical Co.,Ltd. 58
Nantong HI-FUTURE Biology Co., Ltd. 58
Protheragen-ING 58
Aladdin Scientific 58

(1R,2S)-2-fluorocyclopropanecarboxylic acid Spectrum

(1R,2S)-2-fluorocyclopropanecarboxylic acid(167073-08-7)1HNMR

167073-08-7((1R,2S)-2-fluorocyclopropanecarboxylic acid)Related Search:

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(1R,2S)-2-fluorocyclopropanecarboxylic acid Cyclopropanecarboxylic acid, 2-fluoro-, (1R-trans)- (9CI) (1R,2S)-trans-2-Fluorocyclopropanecarboxylic acid 97% Sitafloxacin Impurity 26 (1R,2S)-2-fluorocyclopropane-1-carboxylic acid 167073-08-7