CPI-444
- CAS No.
- 1202402-40-1
- Chemical Name:
- CPI-444
- Synonyms
- V81444;CPI-444;CPD1110;CS-2828;Ciforadenant;CPI-444 AND7648;CPI-444 (V81444);CPI-444, Ciforadenant;CPI-444;CPI 444;CPI444;Ciforadenant (CPI-444)
- CBNumber:
- CB42663793
- Molecular Formula:
- C20H21N7O3
- Molecular Weight:
- 407.43
- MOL File:
- 1202402-40-1.mol
- Modify Date:
- 2025/4/17 18:22:24
| Melting point | 169-171°C |
|---|---|
| Boiling point | 676.9±65.0 °C(Predicted) |
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| form | solid |
| pka | 4.05±0.30(Predicted) |
| color | Beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
CPI-444 Chemical Properties,Uses,Production
Description
CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory. Currently in clinical trials for multiple cancers.
Uses
CPI-444 is an orally administered antagonist to the A2A receptor, and binds to adenosine receptors on the surface of immune cells.
Biological Functions
CPI-444 is a small molecule, oral, checkpoint inhibitor designed to disable a tumor’s ability to subvert attack by the immune system by blocking the binding of adenosine in the tumor microenvironment to the A2A receptor. Adenosine, a metabolite of ATP (adenosine tri-phosphate), is produced within the tumor microenvironment where it may bind to the adenosine A2A receptor present on immune cells and block their activity. CD39 and CD73 are enzymes on the surface of tumor cells and immune cells. These enzymes work in concert to convert ATP to adenosine. In vitro and preclinical studies have shown that dual blockade of CD73 and the A2A receptor may be synergistic.
CPI-444 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | China | 131957 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | China | 29730 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29858 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23541 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | China | 9642 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10473 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6391 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24727 | 58 | Inquiry |
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