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Tipiracil

Tipiracil Structure
CAS No.
183204-72-0
Chemical Name:
Tipiracil
Synonyms
CS-1684;Tipiracil;TAS-1-462;Tipiralacil;Tipiracil HCl;Tipiracil-001-HCl;Reaxys ID: 25670890;Tipiracil-13C-15N2 HCl;Tibiracil Impurities 1;Tipiracil Impurity 4 HCl
CBNumber:
CB42666693
Molecular Formula:
C9H12Cl2N4O2
Molecular Weight:
279.12318
MOL File:
183204-72-0.mol
Modify Date:
2023/6/8 9:02:52
Request For Quotation

Tipiracil Properties

Melting point 245℃ (decomposition)
storage temp. 2-8°C
solubility DMSO (Slightly, Heated), Water (Slightly)
form powder
color white to beige
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
NFPA 704
0
2 0

Tipiracil price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1552 Tipiracil hydrochloride ≥98% (HPLC) 183204-72-0 10MG ₹15451.2 2022-06-14 Buy
Sigma-Aldrich(India) SML1552 Tipiracil hydrochloride ≥98% (HPLC) 183204-72-0 50MG ₹64590.9 2022-06-14 Buy
Product number Packaging Price Buy
SML1552 10MG ₹15451.2 Buy
SML1552 50MG ₹64590.9 Buy

Tipiracil Chemical Properties,Uses,Production

Description

Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase. It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine , a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.

Uses

Tipiracil Hydrochloride serves as a treatment for metastatic colorectal cancer (mCRC). A thymidine phosphorylase inhibitor.

Definition

ChEBI: A hydrochloride obtained by combining tipiracil with one equivalent of hydrochloric acid. Used in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer.

Tipiracil Preparation Products And Raw materials

Raw materials

Preparation Products

Tipiracil Suppliers

Global( 191)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Biophore India Pharmaceuticals Pvt Ltd +91-9100031592 +91-9030907714 Telangana, India 134 58 Inquiry
AUROBINDO PHARMA LTD +91 (40) 6672 1200 New Delhi, India 209 58 Inquiry
INTAS PHARMACEUTICALS LTD +91 79 6157 7000 New Delhi, India 33 58 Inquiry
MSN LABORATORIES PRIVATE LTD +91 40 30438600 New Delhi, India 230 58 Inquiry
BIOPHORE INDIA PHARMACEUTICALS PVT LTD +91-4047474545 New Delhi, India 105 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9343 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Supplier Advantage
Hetero Drugs Limited 58
Biophore India Pharmaceuticals Pvt Ltd 58
AUROBINDO PHARMA LTD 58
INTAS PHARMACEUTICALS LTD 58
MSN LABORATORIES PRIVATE LTD 58
BIOPHORE INDIA PHARMACEUTICALS PVT LTD 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60

Tipiracil Spectrum

Tipiracil(183204-72-0)1HNMR

183204-72-0(Tipiracil)Related Search:

Tipiracil Impurity 2 Tipiracil Impurity des Cl Tipiracil Impurity 5 methyl 5-chloro-2,6-dioxo-3H-pyrimidine-4-carboxylate Tipiracil Impurity 4
Tipiracil Impurity 2 Tipiracil Impurity 1 6-(Chloromethyl)uracil 2-AMINO-1-PYRROLINE HYDROCHLORIDE 2,4(1H,3H)-Pyrimidinedione,5-chloro-6-(chloromethyl)-(9CI)
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Tipiracil Tipiracil (hydrochloride) 2,4(1H,3H)-PyriMidinedione,5-chloro-6-[(2-iMino-1-pyrrolidinyl)Methyl] hydrochloride 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride Tipiracil HCl 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione,hydrochloride 5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione hydrochloride 5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)uracil hydrochloride Tipiracil hydrochloride(TPI) Tipiracil-001-HCl CS-1684 Tipiralacil Reaxys ID: 25670890 Tipiracil-13C-15N2 HClTipiracil HCl 2,4(1H,3H)-Pyrimidinedione,5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-, hydrochloride (1:1) Tipiracil-13C-15N2 HCl 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride 5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydro... Tipiracil Impurity 4 HCl TAS-1-462 Tipiracil Impurity 5 HCl Tibiracil Impurities 1 183204-72-0 18304-72-0 C9H12Cl2N4O2 C9H11ClN4O2HCl C9H12ClN4O2Cl Inhibitors API