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SirReal2

SirReal2 Structure
CAS No.
709002-46-0
Chemical Name:
SirReal2
Synonyms
SirReal2;SirReal2 >=98% (HPLC);Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2;2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide;2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide;Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-;2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
CBNumber:
CB43133754
Molecular Formula:
C22H20N4OS2
Molecular Weight:
420.55
MOL File:
709002-46-0.mol
Modify Date:
2024/7/2 8:55:08
Request For Quotation

SirReal2 Properties

storage temp. Store at -20°C
solubility DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form A crystalline solid
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

SirReal2 Chemical Properties,Uses,Production

Description

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.

Uses

SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor.

SirReal2 Preparation Products And Raw materials

Raw materials

Preparation Products

SirReal2 Suppliers

Global( 66)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 China 9943 58 Inquiry
DC Chemicals 021-58447131 13564518121 China 9412 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9704 58 Inquiry
ShangHai ChuanQian Chemcial Technique Centre 15869524721 China 3713 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
InvivoChem 58
TargetMol Chemicals Inc. 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
Shanghai Chaolan Chemical Technology Center 58
DC Chemicals 58
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58

SirReal2 Spectrum

SirReal2(709002-46-0)1HNMR

709002-46-0(SirReal2)Related Search:

Acetamide 2-Amino-4,6-dimethylpyrimidine
SirReal2 Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]- 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide SirReal2 >=98% (HPLC) Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2 2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide 709002-46-0