Chinese english Japanese Germany Korea

APS-2-79

APS-2-79 Structure
CAS No.
2002381-31-7
Chemical Name:
APS-2-79
Synonyms
CS-2444;APS-2-79;APS 2 79;APS279;APS-279;APS-2-79 (hydrochloride);APS-2-79 hydrochloride >=98% (HPLC);6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride;MAP2K,MAPKK,Inhibitor,Mitogen-activated protein kinase kinase,APS 2 79 hydrochloride,APS279 hydrochloride,inhibit,MEK
CBNumber:
CB43145564
Molecular Formula:
C23H22ClN3O3
Molecular Weight:
423.9
MOL File:
2002381-31-7.mol
Modify Date:
2023/9/4 15:51:00
Request For Quotation

APS-2-79 Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form A crystalline solid

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H361-H372-H410
Precautionary statements  P201-P264-P280-P301+P330+P331-P312
HS Code  2933599590

APS-2-79 Chemical Properties,Uses,Production

Description

APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR). It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes. APS-2-79 (5 μM) inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells. It enhances the efficacy of the MEK inhibitor trametinib , further reducing cell viability in HCT116 and A549 cell lines containing K-Ras mutations, but not B-RAF mutant SK-MEL-239 and A375 cell lines, when used at a concentration of 1 μM.

APS-2-79 Preparation Products And Raw materials

Raw materials

Preparation Products

APS-2-79 Suppliers

Global( 80)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd +8613720134139 China 4695 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Wuhan Boot Biotechnology Co., Ltd. 027-87663101 15827569716 CHINA 6829 58 Inquiry
Shanghai Machine Pure Industrial Co., Ltd. 021-54720761 13524933993 CHINA 6800 58 Inquiry
Immunoway office 400-8787807 18651210423 CHINA 4897 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
InvivoChem 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
Amadis Chemical Company Limited 58
Wuhan Boot Biotechnology Co., Ltd. 58
Shanghai Machine Pure Industrial Co., Ltd. 58
Immunoway office 58

APS-2-79 Spectrum

APS-2-79(2002381-31-7)1HNMR

2002381-31-7(APS-2-79)Related Search:

PD153035 HCl 6,7-Dimethoxy-N-(4-phenoxyphenyl)-
APS-2-79 APS-2-79 (hydrochloride) APS 2 79;APS279;APS-279 CS-2444 APS-2-79 hydrochloride >=98% (HPLC) 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride MAP2K,MAPKK,Inhibitor,Mitogen-activated protein kinase kinase,APS 2 79 hydrochloride,APS279 hydrochloride,inhibit,MEK 2002381-31-7