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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Structure
CAS No.
864725-62-2
Chemical Name:
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid
Synonyms
4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid;Fluralaner-024;Fluralaner Impurity 3;Fluralaner Impurity 2;Fluralaner Impurity 6;Fluralaner N-1 intermediate;Intermediate of FluralanerⅢ;Chemical Formula: C18H12Cl2F3NO3 Molecular Weight: 418.19;4-[5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-3-isoxazolyl]-2-methylbenzoic Acid;Benzoic acid, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-
CBNumber:
CB43364743
Molecular Formula:
C18H12Cl2F3NO3
Molecular Weight:
418.19
MOL File:
864725-62-2.mol
MSDS File:
SDS
Modify Date:
2023/12/14 16:38:12
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4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Properties

Boiling point 511.3±60.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
storage temp. 2-8°C Refrigerator
pka 3.61±0.25(Predicted)

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Chemical Properties,Uses,Production

Uses

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid is an organic intermediate compound used in the synthesis of Fluralaner.

Synthesis

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid is prepared by the reaction of 2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid and 3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole. The steps are as follows:
In a 100 mL three-necked flask, under nitrogen protection, add 3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (700 mg, 1.93 mmoL), 2-methyl-4-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)benzoic acid (560 mg, 2.14 mmoL), potassium acetate (379 mg, 3.86mmol), 1,4-dioxane (15mL), water (1.5mL) and Pd(dppf)Cl2 (141mg, 0.19mmol), incubate the reaction at 85±5 for 8h, stop heating to room temperature, then Water (50 mL) was added to quench and then extracted with dichloromethane (45 mL×2), the organic phases were combined, the organic phase was washed once with saturated brine (50 mL), and then the organic phase was washed with anhydrous sodium sulfate (10.0 g). ) was dried for 2 h, the organic phase was concentrated to dryness under reduced pressure, and the concentrated residue was purified by silica gel column chromatography (developing solvent: n-heptane/ethyl acetate=10:1-3:1) to obtain 4-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid (694 mg, 86%) as a pale yellow solid.
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid synthesis

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Suppliers

Global( 87)Suppliers
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Sam Research Labs +91 9873930190 Hyderabad, India 219 58 Inquiry
Hebei Xinsheng New Material Technology Co., LTD. +86-16632316109 China 1090 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21667 55 Inquiry
Accela ChemBio Inc. +1-858-6993322 United States 19479 58 Inquiry
Shanghai UCHEM Inc. +862156762820 +86-13564624040 China 7121 58 Inquiry
ChemExpress +86-021-58950125 +86-021-58950125; China 598 58 Inquiry
Nanjing Doge Biomedical Technology Co., Ltd +86-25-58227606 +86-15305155328 China 4128 58 Inquiry
Changsha Junyu Chemexpress.co., Ltd +86-13723890100 China 134 58 Inquiry
PNP Biotech Co. Ltd +8618516098983 China 1001 58 Inquiry
Jiangsu Guotai Guomian Trading Co. Ltd. +86-512-58916079 +86-13601562190 China 148 58 Inquiry
Supplier Advantage
Sam Research Labs 58
Hebei Xinsheng New Material Technology Co., LTD. 58
Henan Tianfu Chemical Co.,Ltd. 55
Accela ChemBio Inc. 58
Shanghai UCHEM Inc. 58
ChemExpress 58
Nanjing Doge Biomedical Technology Co., Ltd 58
Changsha Junyu Chemexpress.co., Ltd 58
PNP Biotech Co. Ltd 58
Jiangsu Guotai Guomian Trading Co. Ltd. 58

864725-62-2(4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid)Related Search:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride Fluralaner Impurity 5 3-(4-bromo-3-methylphenyl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole Fluralaner Impurity 4
Fluralaner 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
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4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Fluralaner Impurity 2 Fluralaner Impurity 3 Fluralaner-024 Fluralaner Impurity 6 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid Fluralaner N-1 intermediate Benzoic acid, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl- 4-[5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-3-isoxazolyl]-2-methylbenzoic Acid Chemical Formula: C18H12Cl2F3NO3 Molecular Weight: 418.19 Intermediate of FluralanerⅢ 864725-62-2 API