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Bakuchiol

CAS No.: 10309-37-2

Chemical Name:: Bakuchiol

Synonyms: BAKUCHIOL;Backuchiol;Drupanol;(S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dien-1-yl)phenol;UP 256;BAKUCHIOL;Aids046581;Aids-046581;98%Bakuchiol;BAKUCHIOL(SH)

CBNumber:: CB4365255

Molecular Formula:: C18H24O

Molecular Weight:: 256.38

MOL File:: 10309-37-2.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:09

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Bakuchiol Properties

Boiling point	391℃
Density	0.963
vapor pressure	0Pa at 25℃
refractive index	1.4500 (estimate)
Flash point	177℃
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
form	Liquid
pka	10.10±0.26(Predicted)
color	Oil
optical activity	[α]/D +24.0 to +30.0°, c = 0.1 in chloroform
BRN	3611720
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey	LFYJSSARVMHQJB-WYMLVPIESA-N
LogP	5.09 at 20℃ and pH6.31
Surface tension	43.92mN/m at 1g/L and 20℃

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
WGK Germany	3
RTECS	SL3785000
Toxicity	LD50 orl-mus: 2560 mg/kg MZHUDX 42,646,80

Bakuchiol price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SMB00604	Bakuchiol ≥95%	10309-37-2	20MG	₹28772.85	2022-06-14	Buy
Sigma-Aldrich(India)	68612	Bakuchiol analytical standard	10309-37-2	10MG	₹21379.38	2022-06-14	Buy

Product number	Packaging	Price	Buy
SMB00604	20MG	₹28772.85	Buy
68612	10MG	₹21379.38	Buy

Bakuchiol Chemical Properties,Uses,Production

Description

Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.It has the follow effects: 1.Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2.Protects against acute lung injury.3.Displays neuroprotective and anti-inflammatory effects.

Uses

(S)-Bakuchiol is a meroterpen found in the medicinal resinous shrub Psoralea glandulosa. An analogue of Resveratrol (R150000) with antifungal and anti-tumor effects. Studies have shown that Bakuchiol is a potent cytotoxic agent that exhibiting concentration dependent growth inhibition against leukemia cancer cells.

Safety Profile

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andfumes.

Mode of action

The research found that BAK upregulates the expression of the antiapoptotic molecule Bcl2 and downregulates the expression of the proapoptotic molecules Bax and caspase-3 by activating the silent information regulator 1 (SIRT1) signaling pathway and thereby inhibits mitochondrial damage and ameliorates myocardial IRI. BAK promotes apoptosis in hepatic astrocytes through the caspase-3-dependent pathway and inhibits liver fibrosis. In addition, BAK exerts a protective effect against hepatotoxicity induced by tert-butyl hydroperoxide (tBH), tetrachloromethane (CCl4), and d-galactosamine (D-GalN). BAK (60?mg/kg) treatment significantly reduces edema and pathological changes in lung tissues by inhibiting intense inflammation and exerting protective effects in the lung under sepsis conditions[5-6].

References

1) Adhikari et al. (2007), Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants; J. Clin. Biochem. Nutr., 40 174
2) Kim et al. (2013), Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage; Toxicol. Appl. Pharmacol., 269 109
3) Zhang et al. (2017), Bakuchiol protects against acute lung injury in septic mice; Inflammation, 40 351
4) Kim et al. (2016), Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia; Molecules, 21 E1076
[5] Zhenlong Xin . “Bakuchiol: A newly discovered warrior against organ damage.” Pharmacological research 141 (2019): Pages 208-213.
[6] Jianyu Feng. “Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1.” Apoptosis 71 1 (2016): 532–545.

Bakuchiol Preparation Products And Raw materials

Raw materials

Preparation Products

Bakuchiol Suppliers

Global( 331)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CHEMAZON LABORATORIES	+91 9848551964	Hyderabad, India	1320	58	Inquiry
Venbiotech	+91-9344202656 +91-9940417693	Tamil Nadu, India	14	58	Inquiry
Natural Remedies Pvt Ltd	+91 (80) 4020-9999	New Delhi, India	110	50	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Shanghai Tauto Biotech Co., Ltd.	+86-021-51320588	China	2	58	Inquiry
Chemsigma International Co., Ltd.	+86-18136843612 +86-19951791336	China	1229	58	Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618829768577	China	1250	58	Inquiry
Shaanxi LonierHerb Bio Technology Co Ltd	+86-86-+86-86-029-87551862 +8617702909819	China	2605	58	Inquiry
BINBO BIOLOGICAL CO.,LTD	+8618629063126	China	346	58	Inquiry

Supplier	Advantage
CHEMAZON LABORATORIES	58
Venbiotech	58
Natural Remedies Pvt Ltd	50
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Shanghai Tauto Biotech Co., Ltd.	58
Chemsigma International Co., Ltd.	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Shaanxi LonierHerb Bio Technology Co Ltd	58
BINBO BIOLOGICAL CO.,LTD	58

Anti-aging effects of Bakuchiol
Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with prom....
Dec 26，2023

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P-(3,7-DIMETHYL-3-VINYLOCTA-TRANS-1,6-DIMETHYL) PHENOL 7-dimethyl-1,6-octadienyl)-4-(3-ethenyl-(s-(e))-pheno BACTRIS GASIPAES FRUIT JUICE (S)-Bakuchiol 4-[(1E,3S)-3,7-Dimethyl-3-vinyl-1,6-octadienyl]phenol 4-[(1E,3S)-3-Vinyl-3,7-dimethyl-1,6-octadienyl]phenol 4-[(S,E)-3-Ethenyl-3,7-dimethyl-1,6-octadienyl]phenol Aids046581 Aids-046581 Phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadienyl]- BAKUCHIOL(SH) (S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dienyl)phenol 4-[(1E,3S)-3-Ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol UP 256 4-(3,7-DIMETHYL-3-VINYL-OCTA-1,6-DIENYL)-PHENOL BAKUCHIOL(RG) 4-[(1E,3S)-3-ethenyl-3,7-diMethyl-1,6-octadienyl]-Phenol 4-(3,7-Dimethyl-3-vinylocta-1,6-dien-1-yl)phenol 4-[(1E,3S)-3,7-Dimethyl-3-vinyl-1,6-octadien-1-yl]phenol 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol Nano Liposomal (S)-(+)-Bakuchiol Bakuchiol 98% Bakuchiol, 98%, from Psoralea corylifolia L. Bakuchiol powder Bakuchiol ((S)-(+)-Bakuchiol) Phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]- 98% pure Bakuchiol 98%Bakuchiol (+)-Bakuchiol (1e 3s)-3-enthenyl-3 7-dimethyl octa-1 6-dienyl]phenol TIANFU CHEM 4-(3,7-DIMETHYL-3-VINYL-OCTA-1,6-DIENYL)-PHENOL BAKUCHIOL Drupanol Backuchiol (S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dien-1-yl)phenol Nano-Liposomal BAKUCHIOL, Water-Soluble BAKUCHIOL BAKUCHIOL Cullen corylifolium Psoralen phenol 10309-37-2 10309-27-2 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract