L-Isoserine
- CAS No.
- 632-13-3
- Chemical Name:
- L-Isoserine
- Synonyms
- L-ISOSERINE;(S)-LSOSERINE;(S)-ISOSERINE;L-Isoserine>L-Isoserine USP/EP/BP;(S)-2-HYDROXY-B-ALANINE;(s)-2-hydroxy-β-alanine;Terbutaline Impurity 60;(-)-3-Amino-L-lactic acid;(S)-2-HYDROXY-BETA-ALANINE
- CBNumber:
- CB4394257
- Molecular Formula:
- C3H7NO3
- Molecular Weight:
- 105.09
- MOL File:
- 632-13-3.mol
- Modify Date:
- 2023/10/24 13:48:52
| Melting point | 199~201℃ |
|---|---|
| Boiling point | 386.6±27.0 °C(Predicted) |
| Density | 1.415±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| pka | pK1:2.72(＋1);pK2:9.25(0) (25°C,μ=0.16) |
| color | White to Almost white |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C3H7NO3/c4-1-2(5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 |
| InChIKey | BMYNFMYTOJXKLE-REOHCLBHSA-N |
| SMILES | C(O)(=O)[C@@H](O)CN |
| CAS DataBase Reference | 632-13-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P362+P364 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 2922500090 | |||||||||
| NFPA 704 |
|
L-Isoserine price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 06054 | L-Isoserine ≥98.0% (TLC) | 632-13-3 | 1G | ₹12773.5 | 2022-06-14 | Buy |
| TCI Chemicals (India) | I0828 | L-Isoserine | 632-13-3 | 1G | ₹6400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | I0828 | L-Isoserine | 632-13-3 | 5G | ₹20800 | 2022-05-26 | Buy |
L-Isoserine Chemical Properties,Uses,Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Biological Activity
Research has found that L-isoserine showed the ability to inhibit Aminopeptidase N (APN) at a half-maximal inhibitory concentration (IC50 ) value of 563 μM, which could serve as a new lead compound for further chemical modification and optimization. In addition, it has been reported that L-isoserine-L-leucine dipeptide shows moderate aminopeptidase B inhibitory activity (IC50 of 140 μM). This evidence indicates that the incorporation of an amino acid to L-isoserine may contribute to its inhibitory activity against APN. L-isoserine induces long-lasting effects by increasing the expression of GAT3 (glial GABA transporte) in peri-infarct regions[1-2].
References
[1] Yang K , et al. Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors. Journal of Enzyme inhibition and Medicinal Chemistry, 2011; 27: 302-310.
[2] Lie M , et al. GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice. Journal of Cerebral Blood Flow & Metabolism, 2017; 39.
L-Isoserine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18642 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 13341 | 58 | Inquiry |
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