Ondansetron hydrochloride
- CAS No.
- 103639-04-9
- Chemical Name:
- Ondansetron hydrochloride
- Synonyms
- AKOS NCG1-0013;ondansetron hyd;OndansetronHclUsp28;Ondansetron hydrochl;ODANSETRON HYDROCHLORIDE;Ondansetron hydrochlorid;OndansetronHClmonohydrate;Ondansetron hydrochloride;Ondansetron impurity A CRS;GR 38032;SN 307;NSC 665799
- CBNumber:
- CB4696814
- Molecular Formula:
- C18H22ClN3O2
- Molecular Weight:
- 347.84
- MOL File:
- 103639-04-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/18 17:30:06
| Melting point | 231-232 C |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: >5mg/mL |
| form | powder |
| color | white |
| InChIKey | FELGMEQIXOGIFQ-ZDUSSCGKSA-N |
| CAS DataBase Reference | 103639-04-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H318-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P310+P330-P305+P351+P338+P310 | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 25-36/37/38-50/53-41 | |||||||||
| Safety Statements | 45-37/39-26-61-39 | |||||||||
| RIDADR | UN 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | FE6375500 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933290000 | |||||||||
| NFPA 704 |
|
Ondansetron hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1141 | Ondansetron Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 103639-04-9 | 1G | ₹11279.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O3639 | Ondansetron hydrochloride dihydrate ≥98% (HPLC), powder | 103639-04-9 | 10MG | ₹16822.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O3639 | Ondansetron hydrochloride dihydrate ≥98% (HPLC), powder | 103639-04-9 | 50MG | ₹66368.08 | 2022-06-14 | Buy |
| TCI Chemicals (India) | O0407 | Ondansetron Hydrochloride Dihydrate | 103639-04-9 | 1G | ₹6700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | O0407 | Ondansetron Hydrochloride Dihydrate | 103639-04-9 | 5G | ₹16000 | 2022-05-26 | Buy |
Ondansetron hydrochloride Chemical Properties,Uses,Production
Description
Ondansetron hydrochloride is a selective 5HT3-antagonist approved for the management of nausea and vomiting induced by cancer chemotherapy and radiotherapy. It is reported to have a superior side-effect profile compared with metoclopramide, representing an important advance in the treatment of nausea and vomiting associated with chemotherapy. Ondansetron hydrochloride is the first specific 5HT3-antagonist to reach the market. It is also under investigation for a number of other indications, including anxiety and schizophrenia.
Chemical Properties
White or almost white powder.
Uses
Ondansetron hydrochloride dihydrate has been used as a 5-HT3 antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT3 protein.
General Description
Ondansetron Hydrochloride acts as a 5HT3 (serotonin) antagonist and is a powerful antiemetic drug. It is widely used for the prevention and treatment of nausea and vomiting related to post-operative states, cancer chemotherapy and radiotherapy, and chronic medical illness. It has been found to exhibit inconsistent bioavailability resulting from its poor aqueous solubility and high first-pass hepatic metabolism.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biological Activity
Selective 5-HT 3 receptor antagonist (K i = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.
Ondansetron hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Rampex Labs Private Limited | +91 9168074433 | Telangana, India | 71 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| MOLECRAFT LIFE SCIENCES PVT LTD | +91 9581188881 | Telangana, India | 189 | 58 | Inquiry |
| Sonia Organics | +91-9538454135 +91-9538454135 | Karnataka, India | 28 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Hikal Ltd. | +91-9538444622 +91-8067356100 | Maharashtra, India | 31 | 58 | Inquiry |
| CTX Lifesciences Pvt Ltd | +91-2612399669 +91-7434851395 | Gujarat, India | 28 | 58 | Inquiry |
| Anugraha Chemicals | +91-8041685494 +91-9845939733 | Karnataka, India | 22 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| Rampex Labs Private Limited | 58 |
| Dr. Reddy's Laboratories Ltd | 58 |
| MOLECRAFT LIFE SCIENCES PVT LTD | 58 |
| Sonia Organics | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Cipla Ltd | 58 |
| Hikal Ltd. | 58 |
| CTX Lifesciences Pvt Ltd | 58 |
| Anugraha Chemicals | 58 |