Thapsigargin
- CAS No.
- 67526-95-8
- Chemical Name:
- Thapsigargin
- Synonyms
- hapsigargin;THAPSIGARGIN;Thapsigargin,97%;Thapsigargin (TG);THAPSIGARGIN USP/EP/BP;InSolution? Thapsigargin;Thapsigargin (10 mM in DMSO);Thapsigargin, FroM Thapsia garganica;Azuleno[4,5-b]furan octanoic acid deriv.;Thapsigargin, 99%, from Thapsia garganica
- CBNumber:
- CB4768595
- Molecular Formula:
- C34H50O12
- Molecular Weight:
- 650.75
- MOL File:
- 67526-95-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Boiling point | 597.77°C (rough estimate) |
|---|---|
| Density | 1.1521 (rough estimate) |
| refractive index | 1.6390 (estimate) |
| RTECS | RH0325700 |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | liquid or film |
| pka | 10.57±0.70(Predicted) |
| color | Colorless |
| Sensitive | Light Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
| CAS DataBase Reference | 67526-95-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 36/37/38-42 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29181990 | |||||||||
| NFPA 704 |
|
Thapsigargin price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T9033 | Thapsigargin ≥98% (HPLC), solid film | 67526-95-8 | 0.5MG | ₹12297.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T9033 | Thapsigargin ≥98% (HPLC), solid film | 67526-95-8 | 1MG | ₹19950.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T9033 | Thapsigargin ≥98% (HPLC), solid film | 67526-95-8 | 5MG | ₹70459.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T9033 | Thapsigargin ≥98% (HPLC), solid film | 67526-95-8 | 10MG | ₹112363.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1845 | Thapsigargin Ready Made Solution ≥98% (HPLC), 10?mM in DMSO | 67526-95-8 | 4MG | ₹59185 | 2022-06-14 | Buy |
Thapsigargin Chemical Properties,Uses,Production
Description
Thapsigargin is a naturally occurring sesquiterpene lactone isolated from the umbelliferous plant Thapsia garganica. It is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM). This tumor promoter releases Ca2+ from intracellular stores by specifically inhibiting the endoplasmic reticulum Ca2+-ATPase; it does not directly affect plasma membrane Ca2+-ATPases, Ins 1,4,5-P3 production or protein kinase C activity. This effect is a result of emptying the intracellular calcium stores, which leads to a chain of events that causes apoptosis.
Chemical Properties
Thapsigargin (TG) is colourless film. It is extracted from the plant Thapsia garganica L. with methanol and purified by HPLC. TG is a tumor promoting plant sesquiterpene lactone extract with a unique biological activity as Ca2+ -ATPase inhibitors in animal cells. It is a skin irritant, a platelet activating, inflammatory and tumor promoting agent. TG is toxic and a possible carcinogen.
Uses
THAPSIGARGIN is a widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels.
Definition
ChEBI: Thapsigargin is an organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. It has a role as an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor and a calcium channel blocker. It is a sesquiterpene lactone, an organic heterotricyclic compound and a butyrate ester.
Thapsigargin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 13102 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25298 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | China | 19947 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
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