Rituximab
- CAS No.
- Chemical Name:
- Rituximab
- Synonyms
- CBNumber:
- CB51029377
- Molecular Formula:
- Molecular Weight:
- 0
- MOL File:
- Mol file
Rituximab Chemical Properties,Uses,Production
Description
Rituximab is a genetically engineered, fused mouse/human anti-CD40 monoclonal antibody that targets B lymphocytes by binding specifically to CD20 antigen, a protein found on the surface of B cells at certain stages in their life cycle. Rituximab is composed of two heavy chains of 451 amino acids and two light chains of 213 amino acids with an approximate molecular weight of 145 kDa. Its binding affinity for the CD20 antigen is approximately 8.0 nM.
Uses
Antineoplastic (microtubule inhibitor); monoclonal antibody.
General Description
Rituximab (Rituxan, Chimeric) is an MAb directed againstthe CD20 antigen expressed on the surfaces of normal andmalignant B lymphocytes. The MAb is produced in mammalian(CHO) suspension culture and is a chimeric(murine/human) MAb of the IgG1 κ type. The protein is composed of murine light and heavy chain variable regionsand human constant regions. Rituximab is indicated for thetreatment of patients with relapsed or refractory, low-gradeor follicular, CD20(+) B-cell non-Hodgkin lymphoma.Rituximab binds specifically to antigen CD20 (human Blymphocyte–restricted differentiation antigen, a hydrophobictransmembrane protein expressed on pre-B and matureB lymphocytes). CD20 is a protein of 35 to 37 kDa, and itmay play a role in B cell activation and regulation and maybe a calcium ion channel. The antigen is also expressed onmore than 90% of non-Hodgkin lymphoma B cells but is notfound on hematopoietic stem cells, pro-B cells, normalplasma cells, or other normal tissues. CD20 regulates theearly steps in the activation process for cell cycle initiationand differentiation.
Clinical Use
Rituximab is a sterile, clear, colorless, preservative-free, liquid concentrate formulated for IV administration. It has changed the treatment of rheumatoid arthritis by showing that targeted B-cell therapy in combination with methotrexate can reduce signs and symptoms of rheumatoid arthritis in adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more TNF antagonist therapies. Although B cells once were considered to be one of the main contributing factors in the pathogenesis of rheumatoid arthritis, recent evidence has shown that Tcells, dendritic cells, and macrophages also were involved. Rituximab has rekindled interest in B cells, highlighting their important role in perpetuating the inflammatory process and showing how they may interact with other cell types and contribute to joint inflammation.
Side effects
Side effects include flu-like signs and symptoms such as fever, chills, and nausea. Some people experience an “infusion-reaction complex,” such as difficulty breathing and heart problems, that has resulted in fatalities.
Rituximab Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Congruent Pharmachem Private Limited | 08046073711 | Mumbai, India | 3 | 58 | Inquiry |
| Biovision Medisystem | 08047623299 | Delhi, India | 1 | 58 | Inquiry |
| Wuhan Sunrise Technology Development Co., Ltd. | 027-027-83314682 13554138826 | China | 153 | 62 | Inquiry |
| Shanghai Hanjing Chemicals Co., Ltd. | 021-54285032 13641685631 | China | 76 | 55 | Inquiry |
| kemikalieimport | + 45 - 2034 3359 | Europe | 6699 | 47 | Inquiry |
| ecochem international chemical broker | +45 45 42 34 36 | Europe | 6385 | 66 | Inquiry |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | China | 6463 | 55 | Inquiry |
| Qingdao Jieshikang Biotechnology Co., Ltd. | 4009025885 18754289606 | CHINA | 4012 | 58 | Inquiry |
| Shanghai Han-Xiang Chemical Co., Ltd. | +86 (21) 5027-2946, +86 13818785766 | China | 1039 | 50 | Inquiry |
| Beijing Baiao Innovation Technology Co., Ltd. | 010-5718533 13366620421 | CHINA | 6005 | 58 | Inquiry |