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INDOMETHACIN ESTER, N-HEPTYL-

INDOMETHACIN ESTER, N-HEPTYL- Structure
CAS No.
282728-47-6
Chemical Name:
INDOMETHACIN ESTER, N-HEPTYL-
Synonyms
INDOMETHACIN HEPTYL ESTER;PYBCHCVNKGZCOH-UHFFFAOYSA-N;INDOMETHACIN ESTER, N-HEPTYL-;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester;1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, 1-HEPTYL ESTER;1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER;1-(P-CHLOROBENZOYL)-5-METHOXY-3-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER
CBNumber:
CB5105498
Molecular Formula:
C26H30ClNO4
Molecular Weight:
455.97
MOL File:
Mol file
Modify Date:
2023/9/4 15:51:00
Request For Quotation

INDOMETHACIN ESTER, N-HEPTYL- Properties

Flash point -16 °C
storage temp. −20°C
solubility ≤17mg/ml in ethanol;17mg/ml in DMSO;17mg/ml in dimethyl formamide
form methyl acetate solution

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
Hazard Codes  F,Xi
Risk Statements  11-36-66-67
Safety Statements  16-26-29-33-36
RIDADR  UN 1231 3/PG 2
WGK Germany  1
RTECS  AI9100000
NFPA 704
3
2 0

INDOMETHACIN ESTER, N-HEPTYL- Chemical Properties,Uses,Production

Description

Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC50 for indomethacin heptyl ester for the inhibition of human recombinant COX-2 is 0.04 μM, making it more than 1,700 times more potent as an inhibitor of COX-2 than COX-1. While indomethacin itself has an IC50 of 0.05 μM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC50 of 0.67 μM.

INDOMETHACIN ESTER, N-HEPTYL- Preparation Products And Raw materials

Raw materials

Preparation Products

INDOMETHACIN ESTER, N-HEPTYL- Suppliers

Global( 28)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8740 58 Inquiry
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 China 4428 55 Inquiry
Shanghai YuZn Pharm. Technology Co.,Ltd. 15921286451; 15921286451 China 5063 58 Inquiry
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 China 2992 58 Inquiry
EMD Biosciences, Inc. 858 450 5500 United States 6529 66 Inquiry
VWR International 800 932 5000 United Kingdom 6554 82 Inquiry
SIGMA-RBI 800 736 3690 (Orders) Switzerland 6913 91 Inquiry
Riedel-de Haen AG 800 558-9160 United States 6825 87 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
Guangzhou Isun Pharmaceutical Co., Ltd 55
Shanghai YuZn Pharm. Technology Co.,Ltd. 58
Suzhou Zhixin Biotechnology Co., Ltd. 58
EMD Biosciences, Inc. 66
VWR International 82
SIGMA-RBI 91
Riedel-de Haen AG 87

INDOMETHACIN ESTER, N-HEPTYL- Spectrum

INDOMETHACIN ESTER, N-HEPTYL-(282728-47-6)1HNMR
INDOMETHACIN ESTER, N-HEPTYL- INDOMETHACIN HEPTYL ESTER 1-(P-CHLOROBENZOYL)-5-METHOXY-3-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, 1-HEPTYL ESTER PYBCHCVNKGZCOH-UHFFFAOYSA-N 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester 282728-47-6 Enzymes, Inhibitors, and Substrates Cyclooxygenase (COX) Enzymes Cyclooxygenase Inhibitors Cell Signaling Enzymes Application Index Biochemicals and Reagents BioChemical Cyclooxygenase InhibitorsCancer Research A to Arachidonic Acid Cascade Chemopreventive Agents Cyclooxygenase (COX) Enzymes CyclooxygenaseCell Signaling Enzymes CyclooxygenaseEnzyme Inhibitors by Enzyme Enzyme Inhibitors