Romifidine hydrochloride
- CAS No.
- 65896-14-2
- Chemical Name:
- Romifidine hydrochloride
- Synonyms
- Sedivet;STH 2130Cl;Romifidine HCl;Romifidine Hydrochloride;Romifidine Hydrochloride, Monohydrochloride;N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-ylamine HCl;N-(2-BroMo-6-fluorophenyl)-4,5-dihydro-1H-iMidazol-2-aMine Hydrochloride;1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, monohydrochloride;1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, hydrochloride (1:1)
- CBNumber:
- CB51210096
- Molecular Formula:
- C9H10BrClFN3
- Molecular Weight:
- 0
- MOL File:
- 65896-14-2.mol
- Modify Date:
- 2024/7/14 20:44:35
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White |
| InChI | InChI=1S/C9H9BrFN3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H |
| InChIKey | SDXVSIWCVTYYQN-UHFFFAOYSA-N |
| SMILES | C1(NC2=C(F)C=CC=C2Br)NCCN=1.[H]Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Romifidine hydrochloride Chemical Properties,Uses,Production
Description
Romifidine hydrochloride [N-(2-b romifidineo-6-fluoro-phenyl)- 4,5-dihydro-1H-imidazol-2-amine mono-hydrochloride, C9H9BrFN3, MW 258.1; romifidine] is an imidazole derivative with potent a2-adrenoceptor agonist properties. It is commonly used in equine practice to provide sedation, analgesia, and muscle relaxation. A comparative study reported that an intravenous (i.v.) dose of 80 μg/kg romifidine is equipotent to 1 mg/kg xylazine i.v. and 20 μg/kg detomidine i.v.[1]. Typical signs of sedation include muscle relaxation, decreased head height (HH), diminished responsiveness to external stimuli, and postural abnormalities following romifidine administration. Furthermore, romifidine possesses antinociceptive activity. As an analgesic, it reduces anesthetic requirements for isoflurane in horses.
Uses
An α2 agonist use as a sedative and analgesic.
Mechanism of action
Alpha2 agonists decrease release of neurotransmitters from the neuron. The proposed mechanism whereby they decrease transmission is via binding to presynaptic alpha2 receptors (negative feedback receptors).
References
[1] M. WOJTASIAK-WYPART. “Pharmacokinetic profile and pharmacodynamic effects of romifidine hydrochloride in the horse.” Journal of veterinary pharmacology and therapeutics 35 5 (2012): 478–488.
Romifidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 | China | 27 | 58 | Inquiry |
| Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 | China | 151 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | China | 3882 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15361 | 58 | Inquiry |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | China | 4128 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10986 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43340 | 58 | Inquiry |