paraherquamide

CAS No.: 77392-58-6

Chemical Name:: paraherquamide

Synonyms: VM 29919;paraherquamide;(-)-Paraherquamide A;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizine]-9,10'(10H)-dione, 2',3',8'a,9'-tetrahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)-

CBNumber:: CB51336725

Molecular Formula:: C28H35N3O5

Molecular Weight:: 493.59

MOL File:: 77392-58-6.mol

Modify Date:: 2023/6/8 9:03:09

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paraherquamide Properties

Melting point	244-247° (dec)
alpha	D22 -28° (c = 0.43 in methanol)
storage temp.	Store at -20°C
solubility	DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form	White to off-white powder.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300

Precautionary statements

P264-P270-P301+P310-P321-P330-P405-P501

NFPA 704

	0
4		0

paraherquamide Chemical Properties,Uses,Production

Description

Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC₅₀ = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD₅₀ = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD₅₀ = 14.9 mg/kg).

Uses

Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.

paraherquamide Preparation Products And Raw materials

Raw materials

Preparation Products

paraherquamide Suppliers

Global( 16)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Hangzhou Verychem Science And Technology Co.Ltd	+86-86-57188162785 13606544505	China	1034	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
Shanghai Beiwanta Biotechnology Co., Ltd.	021-67187366 19901745723	China	9254	58	Inquiry
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	China	9707	58	Inquiry
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	China	56070	58	Inquiry
Hangzhou Verychem Science And Technology Co., Ltd	0086-571-88162785 8	China	366	51	Inquiry
Lynnchem	86-(0)29-85992781 17792393971	China	4587	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
BOC Sciences	58
Aladdin Scientific	58
Hangzhou Verychem Science And Technology Co.Ltd	58
Cayman Chemical Company	81
Shanghai Beiwanta Biotechnology Co., Ltd.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
Hangzhou Verychem Science And Technology Co., Ltd	51
Lynnchem	58

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paraherquamide VM 29919 Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizine]-9,10'(10H)-dione, 2',3',8'a,9'-tetrahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)- (-)-Paraherquamide A 77392-58-6