14,15-LEUKOTRIENE D4
- CAS No.
- 75290-64-1
- Chemical Name:
- 14,15-LEUKOTRIENE D4
- Synonyms
- Eoxin D4;14,15-LEUKOTRIENE D4;Glycine, S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
- CBNumber:
- CB5226768
- Molecular Formula:
- C25H40N2O6S
- Molecular Weight:
- 496.66
- MOL File:
- 75290-64-1.mol
- Modify Date:
- 2023/6/8 9:03:08
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
14,15-LEUKOTRIENE D4 Chemical Properties,Uses,Production
Description
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.
Uses
Eoxin D4 is synthesized via the 15-lipoxygenase-1 pathway in human eosinophils. Eoxins are proinflammatory arachidonic acid metabolites produced by mast cells.
14,15-LEUKOTRIENE D4 Preparation Products And Raw materials
Raw materials
Preparation Products
14,15-LEUKOTRIENE D4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BIOMOL INTERNATIONAL, LP | (800) 942-0430 | United States | 1503 | 77 | Inquiry |
| Tebu-bio | France | 251 | 75 | Inquiry | |
| Biomol Feinchemikalien GmbH | 49-40-8532600 | Germany | 479 | 74 | Inquiry |
| Shanghai Hao Zhun Biological Technology Co., Ltd. | 15800340161 | CHINA | 6846 | 58 | Inquiry |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | China | 11289 | 58 | Inquiry |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | China | 7979 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8736 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 28070 | 58 | Inquiry |