methyl 3-bromo-4-methyl-5-nitropicolinate
![methyl 3-bromo-4-methyl-5-nitropicolinate Structure](CAS/GIF/1150618-07-7.gif)
- CAS No.
- 1150618-07-7
- Chemical Name:
- methyl 3-bromo-4-methyl-5-nitropicolinate
- Synonyms
- methyl 3-bromo-4-methyl-5-nitropicolinate;methyl3-bromo-4-methyl-5-nitropyridine-2-carboxylate;methyl 3-bromo-4-methyl-5-nitropicolinate ISO 9001:2015 REACH;3-Bromo-4-methyl-5-nitro-2-pyridinecarboxylic acid methyl ester;2-Pyridinecarboxylic acid, 3-bromo-4-methyl-5-nitro-, methyl ester
- CBNumber:
- CB52474727
- Molecular Formula:
- C8H7BrN2O4
- Molecular Weight:
- 275.06
- MOL File:
- 1150618-07-7.mol
- Modify Date:
- 2022/8/26 12:27:33
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
methyl 3-bromo-4-methyl-5-nitropicolinate Chemical Properties,Uses,Production
Preparation
Methyl-3-bromo-4-methyl-5-nitropicolinate synthesis: 3-bromo-2-iodo-4-methyl-5-nitropyridine (129.0 g, 0.38 mol) and (Ph3P)2PdCl2 (7.92 g, 3 mol%) were suspended in CH3CN (1300 mL) and MeOH (430 mL) and Et3N (79.3 mL, 1.5 eq) was added. The mixture was transferred to a steel 5000 mL pressure vessel, 4 bar of CO pressure was applied and the reaction mixture was slowly heated to 80 oC. Subsequently, it was stirred for 5 h at this temperature, then allowed to cool overnight. The volatiles were removed in vacuo, the residue was stirred in EtOAc (1000 mL) and filtered. The residue was extracted with EtOAc (2*250 mL) and the combined filtrates were washed with brine (1000 mL) and dried on Na2SO4. The volatiles were removed in vacuo, affording 120 g of a brown oil. This was coated on 120 g of silicagel and purified by column chromatography (3500 g of silica gel, EtOAc/heptane 1:3, KMnO4 staining). The appropriate fractions were combined and concentrated to give Methyl-3-bromo-4-methyl-5-nitropicolinate as a beige solid (63.5 g, 61%).
methyl 3-bromo-4-methyl-5-nitropicolinate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 3-bromo-4-methyl-5-nitropicolinate Suppliers
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SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2688 | 50 | Inquiry |
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Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |