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Regorafenib (Hydrochloride)

Regorafenib (Hydrochloride) Structure
CAS No.
835621-07-3
Chemical Name:
Regorafenib (Hydrochloride)
Synonyms
Regofini;Regafenib HCL;Regorafenib HC;Regorafenib HCl;Regafenib hydrochloride;BAY73-4506 hydrochloride;egorafenib (Hydrochloride);5-Diiodotyrosine Dihydrate;Regorafenib (Hydrochloride);Regorafenib HCl (BAY-73-4506)
CBNumber:
CB52624290
Molecular Formula:
C21H16Cl2F4N4O3
Molecular Weight:
519.2763528
MOL File:
835621-07-3.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:11
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Regorafenib (Hydrochloride) Properties

storage temp. Store at -20°C
solubility ≥ 25.95 mg/mL in DMSO, ≥ 8.75 mg/mL in EtOH with ultrasonic and warming
form Powder
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

Regorafenib (Hydrochloride) Chemical Properties,Uses,Production

Uses

BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

in vitro

Regorafenib potently inhibits VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with an IC50 of 3 nM. In HAoSMCs, regorafenib inhibits PDGFR-β autophosphorylation after stimulation with PDGF-BB, with an IC50 of 90 nM. Regorafenib inhibits the proliferation of VEGF165-stimulated HUVECs, with an IC50 of 3 nMf. Regorafenib causes a concentration-dependent decrease in Hep3B cell growth, having an IC50 of 5 μM. Regorafenib subsequently increases the levels of phospho-c-Jun, a JNK target, but not total c-Jun in Hep3B cells.

in vivo

Regorafenib effectively inhibits growth of the Colo-205 xenografts in the dose range of 10-100 mg/kg reaching a TGI of 75% at day 14 at the 10 mg/kg dose. In the MDA-MB-231 model, regorafenib is highly efficacious at a dose as low as 3 mg/kg, resulting in a significant TGI of 81%, which increases to 93% at doses of 10 and 30 mg/kg, where tumor stasis is reached.

References

[1] Phan, Chiuyen et al. “Isomorphous Crystals Formed by the Similar Supramolecular Motifs in Sorafenib Hydrochloride and Regorafenib Hydrochloride Salts.” 2019. 0.

Regorafenib (Hydrochloride) Preparation Products And Raw materials

Raw materials

Regorafenib

Preparation Products

Regorafenib (Hydrochloride) Suppliers

Global( 126)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Yangzhou Qinyuan Pharmatech Co.,ltd +86-18752526868 China 71 58 Inquiry
Hebei Yanxi Chemical Co., Ltd. +86-17531190177; +8617531190177 China 5916 58 Inquiry
Henan Bao Enluo International TradeCo.，LTD +86-17331933971 +86-17331933971 China 2503 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD +8618957127338 China 2141 58 Inquiry
SHANDONG ZHI SHANG CHEMICAL CO.LTD +86 18953170293 China 2931 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Yangzhou Qinyuan Pharmatech Co.,ltd 58
Hebei Yanxi Chemical Co., Ltd. 58
Henan Bao Enluo International TradeCo.，LTD 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Zhejiang ZETian Fine Chemicals Co. LTD 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 58
BOC Sciences 58

Regorafenib (Hydrochloride) Spectrum

Regorafenib (Hydrochloride)(835621-07-3)1HNMR

835621-07-3(Regorafenib (Hydrochloride))Related Search:

4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide (S,S')-3-METHYL-1-(2-PIPERIDINOPHENYL)BUTYLAMINE, N-ACETYL-GLUTAMATE SALT 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate Regorafenib Bortezomib
Abiraterone
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BAY73-4506 hydrochloride 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrochloride Regafenib HCL Regafenib hydrochloride 2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, monohydrochloride 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrochloride (1:1) 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydr Regorafenib (Hydrochloride) 5-Diiodotyrosine Dihydrate egorafenib (Hydrochloride) Regorafenib HCl (BAY-73-4506) Powder Regorafenib Hydrochloride CAS Regorafenib Hydrochloride/BAY73-4506 hydrochloride Regorafenib HC 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide hydrochloride Regorafenib HCl Regofini 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrochloride (1:1) 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-Pyridinecarboxamide hydrochloride (1:1) 4-4-4-Chloro-3-(trifluoromethyl)phenylaminocarbonylamino-3-fluorophenoxy-N-methylpyridin-2-carboxamide HCl 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydrochloride 835621-07-3 C21H15ClF4N4O3HCl C21H16Cl2F4N4O3 C21H15ClF4N4O3ClH