(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
- CAS No.
- 401564-36-1
- Chemical Name:
- (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
- Synonyms
- Teneint-G;Tenaligliptin;Teneligptin interMediate B;Teneligliptin Intermediate;Teneligptin interMediate-1;Teneliglitpin intermediates;Teneligliptin Intermediate-1;Ethyl(2)-chloro[(4-methoxyphenyl)hydrazono]ethanoate;(S)-1-Boc-5-(thiazolidine-3-carbonyl)pyrrolidin-3-one;(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecar
- CBNumber:
- CB52651238
- Molecular Formula:
- C13H20N2O4S
- Molecular Weight:
- 300.37
- MOL File:
- 401564-36-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/11/6 13:03:30
| Boiling point | 492℃ |
|---|---|
| Density | 1.305 |
| Flash point | 251℃ |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | -1.22±0.20(Predicted) |
| form | Solid |
| color | Pale Yellow to Light Yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Chemical Properties,Uses,Production
Uses
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.
Synthesis
To (2S)-1-tertbutyloxycarbonyl-4-oxa-tetramethyleneimine-2-carboxylic
acid (60.0kg), thiazolidine (30.3kg) and the solution
of N-diisopropylethylamine (118kg) in ethyl acetate (595kg), adds the
solution of 28w% propyl phosphonous acid anhydride (cyclic trimer)
in ethyl acetate (446kg) at 2 ℃-7 ℃, and reaction mixture is stirred 2
hours at 2 ℃-4 ℃.To this reaction mixture, add 15w% aqueous citric acid
solution (600kg) for distributing, and ethyl acetate for water layer
(271kg) is extracted.
The ethyl acetate layer obtaining is mixed, and use
successively 10w% ammonium dibasic phosphate aqueous solution (600kg)
and water (300kg) washing. Ethyl acetate layer is concentrated into
residual quantity 300L, normal heptane (739kg), 23 ℃ of-25 ℃ of
interpolations, and is stirred this mixture 1 hour at 23 ℃-25 ℃, and
stir 2 hours at 1 ℃-5 ℃.
The crystal of precipitation is collected by
filtration, is used normal heptane (164kg) washing drying under reduced
pressure to produce (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester (67.8kg, yield 86%).
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1262 | 58 | Inquiry |
| Firmus Laboratories Pvt Ltd | +918008045456 | Hyderabad, India | 41 | 58 | Inquiry |
| HEMA PHARMACEUTICALS PVT LTD | +91-9537936912 +91-9537936912 | Gujarat, India | 48 | 58 | Inquiry |
| 3A Chemie Private Limited | +91-91-712-2564285 +91-9766589212 | Maharashtra, India | 57 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Aventus Labs | +91-7021872517 +91-9324342304 | Maharashtra, India | 168 | 58 | Inquiry |
| Vercali Pharma | 9603199909 | Hyderabad, India | 43 | 58 | Inquiry |
| Soujanya Life Sciences | +91-9717304919 +91-9717304919 | Mumbai, India | 17 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Cubane Pharmaceuticals LLP | +91-9825323764 +91-9825323764 | Gujarat, India | 75 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| Firmus Laboratories Pvt Ltd | 58 |
| HEMA PHARMACEUTICALS PVT LTD | 58 |
| 3A Chemie Private Limited | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Aventus Labs | 58 |
| Vercali Pharma | 58 |
| Soujanya Life Sciences | 58 |
| Ralington Pharma | 58 |
| Cubane Pharmaceuticals LLP | 58 |