UNC0646

CAS No.: 1320288-17-2

Chemical Name:: UNC0646

Synonyms: CS-792;UNC0646;UNC0646/UNC-0646;UNC 0646;UNC0646;UNC-0646;N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine;N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;(1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE;H3K9me2,KMT1D,chromatin,EHMT1,Histone Methyltransferase,UNC-0646,SAR,inhibit,G9a,GLP,PKMT,UNC0646,Inhibitor,cell-penetration,p53;N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;4-Quinazolinamine, N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-

CBNumber:: CB52667561

Molecular Formula:: C36H59N7O2

Molecular Weight:: 621.9

MOL File:: 1320288-17-2.mol

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

UNC0646 Properties

Boiling point	754.6±70.0 °C(Predicted)
Density	1.128±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: soluble2mg/mL, clear (warmed)
pka	9.34±0.70(Predicted)
form	powder
color	white to beige

SAFETY

Risk and Safety Statements

WGK Germany	3

UNC0646 price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0633	UNC0646 ≥98% (HPLC)	1320288-17-2	5MG	₹15995.1	2022-06-14	Buy
Sigma-Aldrich(India)	SML0633	UNC0646 ≥98% (HPLC)	1320288-17-2	25MG	₹64468.8	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0633	5MG	₹15995.1	Buy
SML0633	25MG	₹64468.8	Buy

UNC0646 Chemical Properties,Uses,Production

Description

G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases. UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line. This compound selectively targets the corepressor function of G9a without affecting its ability to act as a coactivator with glucocorticoid receptor.

Uses

UNC0646 is a novel Protein lysine methyltransferase G9a inhibitor.

UNC0646 Preparation Products And Raw materials

Raw materials

Preparation Products

UNC0646 Suppliers

Global( 64)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry
Riedel-de Haen AG	800 558-9160	United States	6825	87	Inquiry
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	China	3574	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Riedel-de Haen AG	87
Changzhou Chenhong Biotechnology Co., Ltd.	58

UNC0646 Spectrum

UNC0646(1320288-17-2)MS

1320288-17-2(UNC0646)Related Search:

UNC0321 (trifluoroacetate salt) UNC2541 UNC 1079 UNC 0224 1-Methyl-4-piperidone

N-Methylpiperidine 3-Hydroxy-1-methylpiperidine UNC3866 UNC0379 UNC 669

UNC2250 UNC-1215 UNC-926 Hydochloride UNC569 NUC-7738

UNC2025 UNC0638 UNC-0642

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UNC0646 N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine UNC0646/UNC-0646 N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine (1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE UNC 0646;UNC0646;UNC-0646 CS-792 4-Quinazolinamine, N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]- H3K9me2,KMT1D,chromatin,EHMT1,Histone Methyltransferase,UNC-0646,SAR,inhibit,G9a,GLP,PKMT,UNC0646,Inhibitor,cell-penetration,p53 1320288-17-2 C36H59N7O2