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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >Microtubule Associated inhibitors >CW069

CW069

CW069 Structure
CAS No.
1594094-64-0
Chemical Name:
CW069
Synonyms
CW069;CS-1425;CW069; CW 069;CW069 USP/EP/BP;CW-069,Inhibitor,Kinesin,inhibit,CW 069;(S)-2-(2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO)-5-IODOBENZOIC ACID;2-[(2S)-2-(Benzylamino)-3-phenylpropanamido]-5-iodobenzoic acid;5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid;Benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-
CBNumber:
CB52681121
Molecular Formula:
C23H21IN2O3
Molecular Weight:
500.33
MOL File:
1594094-64-0.mol
Modify Date:
2024/7/2 8:55:11
Request For Quotation

CW069 Properties

Boiling point 666.0±55.0 °C(Predicted)
Density 1.559±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility ≥50 mg/mL in DMSO; insoluble in H2O; ≥51.6 mg/mL in EtOH
form solid
pka 2.69±0.10(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

CW069 Chemical Properties,Uses,Production

Description

CW069 is an allosteric inhibitor of KIFC/HSET (IC50 = 75 μM), a microtubule motor protein involved in bipolar spindle assembly and centrosome clustering. It increases the number of multipolar spindles in N1E-115 mouse neuroblastoma cells with supernumerary centrosomes when used at concentrations of 100 and 200 μM, without affecting the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells. CW069 inhibits proliferation of N1E-115, but not NHDF, cells (IC50s = 86 and 181 μM, respectively).

Uses

CW 069 is an allosteric inhibitor of the microtubule motor protein HSET which induces multipolar mitoses only in cells containg supernumerary centrosomes.

CW069 Preparation Products And Raw materials

Raw materials

Preparation Products

CW069 Suppliers

Global( 75)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Shanghai Zeye Biotechnology Co., Ltd. 021-61998551 13122364865 China 9771 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
Dideu Industries Group Limited 58
InvivoChem 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Shanghai Zeye Biotechnology Co., Ltd. 58

CW069 Spectrum

CW069(1594094-64-0)1HNMR

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CW069 (S)-2-(2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO)-5-IODOBENZOIC ACID 5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid Benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]- CW069; CW 069 CS-1425 2-[(2S)-2-(Benzylamino)-3-phenylpropanamido]-5-iodobenzoic acid CW069 USP/EP/BP CW-069,Inhibitor,Kinesin,inhibit,CW 069 1594094-64-0 Inhibitors